在高血压成年人中,甘油三糖指数和BMI调整后的骨肌肉质量指数之间的负相关性
Qingqing Zhu1, Ting Zhang1, Iokfai Cheang1
1Department of Cardiology, Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, Guangzhou Road 300, Nanjing, 210029, China.
BMC musculoskeletal disorders
|July 13, 2023
概括
胰岛素耐药性,由甘油三糖 (TyG) 指数表示,与高血压个体的较低肌肉质量有关. 这表明胰岛素耐药性对这一群体的骨肌肉质量产生负面影响.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 老年学是指老年学的学科.
背景情况:
- 三甘油糖 (TyG) 指数是胰岛素耐药性的标志物.
- 高血压是心血管疾病的已知危险因素.
- 胰岛素抵抗对高血压患者肌肉质量的影响尚不清楚.
研究的目的:
- 在高血压人群中研究TyG指数和肌肉质量之间的关系.
- 探索胰岛素抵抗如何影响高血压患者的骨肌肉质量.
主要方法:
- 分析了2011-2018年国家健康和营养检查调查 (NHANES) 中高血压成年人的数据.
- 计算TyG指数和BMI调整后的骨肌肉质量指数 (SMI).
- 使用多变量线性回归和受限立方线 (RCS) 回归模型评估关系.
主要成果:
- 总共分析了1633名高血压参与者.
- 较高的TyG指数四分位数与显著较低的SMI有关 (β = -5.27;95% CI: -9.79至 -0.75).
- RCS回归显示了TyG指数和SMI之间的负线性趋势;非吸烟女性的分层分析表明SMI下降随着TyG指数的增加.
结论:
- 在高血压患者的TyG指数和SMI之间存在显著的负相关性.
- 这些发现表明,胰岛素抵抗对高血压患者的肌肉质量产生不利影响.
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