在健康的南非儿童中,肝脏过渡性弹性体检值
Penelope C Rose1, Mark F Cotton2,3, Kennedy Otwombe4
1Department of Paediatrics and Child Health, Tygerberg Hospital and Stellenbosch University, PO Box 241, Cape Town, 8000, South Africa. pcrose@sun.ac.za.
BMC pediatrics
|July 13, 2023
概括
过渡性弹性图 (TE) 在健康的南非儿童中确定正常的肝硬度和受控衰减参数 (CAP) 范围. 肝硬度随着年龄的增长而增加,在男孩中更高,而CAP与BMI相关.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 儿科胃肠病学 儿科胃肠病学
- 医疗成像医学成像
背景情况:
- 过渡性弹性图 (TE) 是一种非侵入性的超声波技术,用于评估肝纤维化和肝硬化.
- 在全球范围内,儿童TE参数的正常参考范围尚未得到充分确立.
- 这项研究旨在在健康的南非儿科队列中定义TE值.
研究的目的:
- 在健康的南非儿童中确定肝硬度和受控衰减参数 (CAP) 的参考范围.
- 研究年龄,性别和种族对这些参数的影响.
- 为儿童肝脏健康评估建立规范性数据.
主要方法:
- 对104名健康的南非儿童 (年龄在7.9-17.7岁) 进行了横截面分析.
- 从HIV阴性队列中招募儿童,不包括超重,肥胖或肝脏疾病/风险因素的儿童.
- 收集了临床数据,人体测量和TE/CAP测量.
主要成果:
- 男孩的中位肝硬度为5.2kPa,女孩为4.6kPa,随着年龄的增长而增加 (r=0.39,p<0.001).
- 男孩的肝硬度明显高于女孩 (p=0.004),没有种族差异.
- 中位数CAP为179dB/m,与BMIz-score正相关,但不与年龄或性别相关.
结论:
- 在健康的南非儿童中,肝硬度值随着年龄的增长而增加,在男孩中则更高.
- 控制减弱参数 (CAP) 值受到BMI的影响,而不是这个队列中的年龄或性别.
- 这些发现为解释南非儿科人口中TE提供了关键的规范性数据.
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