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Updated: Jul 23, 2025

Three-dimensional Quantification of Dendritic Spines from Pyramidal Neurons Derived from Human Induced Pluripotent Stem Cells
10:18

Three-dimensional Quantification of Dendritic Spines from Pyramidal Neurons Derived from Human Induced Pluripotent Stem Cells

Published on: October 10, 2015

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鉴定了一种精神病风险基因NISCH在3p21.1 GWAS位点介导树状脊柱形态发生和认知功能

Zhi-Hui Yang1,2, Xin Cai1,2, Zhong-Li Ding1,2

  • 1Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.

BMC medicine
|July 13, 2023
PubMed
概括

研究人员确定了与精神分裂症和双相情感障碍相关的精神病风险基因NISCH,该基因影响大脑细胞结构和认知功能. 针对尼沙林的抗高血压药物显示出治疗这些心理健康状况的潜力.

关键词:
元素Alu 是一个元素.树突性脊柱形态生成 树突性脊柱形态生成尼斯赫尼斯赫尼斯赫尼斯赫尼斯精神疾病 精神疾病工作记忆 工作记忆

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The complex relationship between genetics and psychology is observable through common biological components such...
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Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
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Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
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Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
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