在双胞胎中,带血的代谢表型与带血相关的变化
Xiaoyu Liu1, Jing Yang2, Rui Ran1
1Department of Obstetrics and Gynecology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Nutrition & metabolism
|July 13, 2023
概括
单 (MC) 双胞胎与二 (DC) 双胞胎相比,表现出不同的带血代谢物概况. 这些代谢差异,特别是谷氨,三和脂肪酸途径,与双胞胎的出生体重结果有关.
科学领域:
- 围产儿医学 围产儿医学
- 代谢学 代谢学 代谢学
- 双胞胎妊娠研究 双胞胎妊娠研究
背景情况:
- 单子 (MC) 双胞胎比二子 (DC) 双胞胎有更高的不良周产期结果的风险,通常是由于胎盘血管解剖.
- 研究了无并发性MC和DC双胞胎怀孕中的带血代谢.
- 代谢物概况与后代的结果有关,特别是出生体重.
研究的目的:
- 为了比较不复杂的MC和DC双胞胎怀孕之间的带血的代谢概况.
- 为了确定MC和DC双胞胎之间不同的特定代谢物和代谢途径.
- 探索代谢差异与双胞胎出生体重异常之间的关系.
主要方法:
- 基于气色谱-质谱的代谢学研究在49对无并发双胞胎 (25MC,24DC) 的带静脉血液样本上进行.
- 通过部分最小平方差分分析和途径分析,确定并分析了152种代谢物.
- 用通用估计方程 (GEE) 模型来评估代谢概况和出生体重异常之间的相关性.
主要成果:
- 在MC和DC双胞胎之间观察到代谢物概况的显著差异.
- 在MC和DC双胞胎对中,分别观察到了2-氧谷氨酸和尼古丁胺胺水平的特定差异.
- 与DC双胞胎相比,MC双胞胎的新陈代谢途径包括谷氨 (GSH),三和脂肪酸代谢的下调. 咖啡因和D5度与出生体重正相关.
结论:
- 改变的带血代谢物有助于不复杂的MC与DC双胞胎的独特特征.
- 双胞胎胆性影响双胞胎之间的代谢相互作用,并与出生体重异常有关.
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