CD271激活可以防止皮肤状细胞癌的低至高风险进展,并改善治疗结果
Marika Quadri1, Natascia Tiso2, Francesco Musmeci3
1DermoLAB, Department of Surgical, Medical, Dental and Morphological Science, University of Modena and Reggio Emilia, Via Del Pozzo 71, 41124, Modena, Italy.
Journal of experimental & clinical cancer research : CR
|July 13, 2023
概括
在皮肤状细胞癌 (cSCC) 中的神经受体CD271的上调促进细胞分化并减少转移. CD271增强治疗反应,表明其作为预防高风险cSCC的药物点的潜力.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 分子生物学分子生物学
背景情况:
- 皮肤状细胞癌 (cSCC) 是一种流行性皮肤癌,发病率越来越高.
- 由于局部入侵和转移,高级cSCC带来了挑战.
- 神经营养素受体CD271在上皮瘤 (包括cSCC) 中的作用尚不清楚.
研究的目的:
- 为了研究CD271在皮肤状细胞癌中的功能.
- 探索CD271对cSCC分化,入侵和治疗反应的影响.
- 评估CD271在cSCC中转移和炎症中的作用.
主要方法:
- 确定的患者衍生cSCC球体 (低风险和高风险).
- 在对CD271调制的反应中分析了组织学特征,增殖和入侵.
- 使用斑马鱼异种移植和2D/3D模型研究转移和治疗效果在体外和体内.
主要成果:
- 在高度分化的cSCC中,CD271被上调,与分化增加和恶性瘤标志物减少相关.
- 在斑马鱼模型中,CD271过度表达降低了cSCC细胞的侵入性,并抑制了转移.
- CD271活性与Trk抑制协同作用,改善了光动力学治疗和化疗的结果.
结论:
- CD271上调可能会阻止cSCC向高风险瘤的进展.
- CD271促进分化并增强cSCC中的治疗反应.
- CD271代表了一种有前途的治疗点,用于治疗cSCC的药物开发.
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