在SARS-CoV-2疫苗接种时,抗体Fc-effector功能减弱和增强
X Tong1, R P McNamara1, M J Avendaño2
1Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, 02139, USA.
Nature communications
|July 13, 2023
概括
像CoronaVac和Pfizer/BNT162b2这样的COVID-19疫苗诱导了超出中和的抗体依赖效应因子功能. 用mRNA疫苗进行增强可以增强这些关键的免疫反应,即使对抗Omicron变种.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 病毒学 病毒学
背景情况:
- 针对SARS-CoV-2疫苗的快速开发,包括非活化病毒 (CoronaVac) 和mRNA (Pfizer/BNT162b2) 平台,对于控制COVID-19大流行至关重要.
- 虽然中和抗体得到了很好的研究,但疫苗诱导的抗体的Fc-effector功能,这有助于疾病减弱,是不太了解的.
研究的目的:
- 纵向研究和比较由CoronaVac和BNT162b2疫苗诱导的Fc-effector概况,直到接种疫苗后五个月.
- 评估mRNA疫苗增强对Fc-effector功能的影响,包括对像Omicron这样的SARS-CoV-2变种的反应.
主要方法:
- 系统血清学被用来纵向跟踪Fc-effector功能.
- 在接受两剂CoronaVac或BNT162b2疫苗的个体中分析了抗体概况.
主要成果:
- 冠状病毒诱导的抗体反应比BNT162b2减缓得更慢,尽管总体水平仍然较低.
- 用mRNA疫苗促进CoronaVac接种者显著增强抗体功能反应和幽默宽度,包括对抗Omicron变种.
结论:
- 疫苗平台诱导幽默性免疫反应,超出病毒中和范围,包括Fc-effector功能.
- 这些Fc-effector功能表现出明显的衰减动力学,并且可以通过同源或异源疫苗增强来有效地恢复和扩大.
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