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缺血性中风后甲状腺功能下降与中风严重程度有关.

Evgeny Sidorov1,2, Aruna Paul3, Chao Xu4

  • 1Department of Neurology, University of Oklahoma Health Sciences Center, 920 Stanton L. Young Blvd #2040, Oklahoma City, OK, 73104, USA. evgeny-sidorov@ouhsc.edu.

Thyroid research
|July 13, 2023
PubMed
概括
此摘要是机器生成的。

在急性缺血性中风 (AIS) 后,甲状腺激素水平,包括自由三甲状腺素 (fT3) 在内,短暂下降. 更高的中风严重程度与更大的fT3减少有关,这表明甲状腺功能变化可能会影响恢复.

关键词:
急性缺血性中风是一次急性缺血性中风.脑卒中的严重程度 脑卒中严重程度甲状腺激素 甲状腺激素甲状腺素是什么 甲状腺素三氨基氨酸 (Triiodothyronine) 是一种氨酸.

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科学领域:

  • 神经学 神经学
  • 内分泌学 在内分泌学.
  • 内部医学 内部医学

背景情况:

  • 甲状腺激素对大脑功能至关重要.
  • 经过急性缺血性中风 (AIS) 后的低三甲氨酸 (fT3) 水平与较差的结局相关.
  • 在AIS之后甲状腺功能的纵向动态尚不清楚.

研究的目的:

  • 在缺血性中风后纵向评估甲状腺激素水平.
  • 为了研究中风严重程度和甲状腺功能变化之间的关系.

主要方法:

  • 追踪甲状腺刺激激素 (TSH),ft3和自由甲状腺素 (ft4) 水平的前性研究.
  • 在超急性 (24小时内),急性 (3-5天) 和慢性 (3-6个月) 阶段进行评估.
  • 混合回归模型用于分析激素动态和国家卫生研究院中风量表 (NIHSS) 相关性.

主要成果:

  • 跨阶段的TSH水平显示非显著下降.
  • fT3水平从超急性阶段显著下降到急性阶段,然后在慢性阶段恢复 (p < 0.01).
  • fT4水平急剧下降,并在慢性阶段显示非显著的增加 (p = 0.02).
  • 增加的NIHSS得分与fT3从超急性到急性阶段的显著下降有关 (p < 0.01).

结论:

  • 缺血性中风与甲状腺激素的短暂下降有关,特别是fT3.3.
  • 脑中风的严重程度似乎影响了这些甲状腺功能变化.
  • 需要进一步的研究来探索甲状腺功能正作为改善中风结果的潜在治疗策略.