肠道微生物通过氧化还原调节参与胃肠道癌症
Wang Yangyanqiu1,2,3, Chu Jian1,4,3, Yang Yuqing1,3
1Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, No. 1558, Sanhuan North Road, Wuxing District, Huzhou, 313000, Zhejiang Province, China.
Gut pathogens
|July 13, 2023
概括
胃肠道微生物通过氧化还原不稳定性影响癌症的发展,影响细胞过程. 了解这些微生物氧化还原反应为预防和治疗胃肠道癌症提供了新的策略.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
背景情况:
- 胃肠道 (GI) 癌症是全球癌症死亡的主要原因.
- 人们越来越认识到肠道微生物在癌症发病和进展中的重要作用.
- 机制包括微生物失调,代谢物分泌和肠道粘膜屏障的破坏.
研究的目的:
- 在癌症的背景下,审查肠道微生物,它们的代谢物和宿主的氧化还原平衡之间的复杂关系.
- 探索微生物的氧化还原反应及其对宿主细胞的氧化还原影响如何影响肠道癌症的发展.
- 为胃肠道癌症预防和治疗策略提供一个新的视角,针对微生物与宿主的氧化还原相互作用.
主要方法:
- 文献综述侧重于研究肠道微生物,宿主氧化还原状态和癌症的研究.
- 对肠道细胞中微生物活动,氧化还原失衡,氧化应激和DNA损伤之间的机制的分析.
- 检查微生物氧化还原相关代谢物 (如SCFA,H2S,NO) 在癌症病原发生中的作用.
主要成果:
- 胃肠道微生物失调可以导致氧化还原不稳定,诱导氧化应激,DNA损伤和胃肠道细胞的突变.
- 微生物代谢物,如短链脂肪酸,硫化和氧化,直接影响肠道逆氧化水平和癌症进展.
- 宿主胃肠道细胞和与癌症相关的胃肠道微生物都表现出相互关联且在瘤发生过程中至关重要的氧化还原反应.
结论:
- 胃肠道微生物,宿主还氧化状态和癌症发展之间的相互作用是复杂而重要的.
- 针对微生物的氧化还原反应和恢复氧化还原平衡,为新的胃肠道癌症疗法提供了一个有前途的途径.
- 对微生物与宿主的氧化还原相互作用的进一步研究可以解锁肠道癌症的新预防和治疗策略.
相关概念视频
02:17The Tumor Microenvironment
6.7K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.7K
02:53Adaptive Mechanisms in Cancer Cells
5.8K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.8K
02:59Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
01:46Electron Transport Chain: Complex I and II
14.5K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
14.5K
01:50What is Monogastric Digestion?
71.6K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
71.6K
03:03mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K