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Updated: Jul 23, 2025

Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes
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Published on: January 12, 2024

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亲和性和合作性调节三元复合体的形成,以推动向的蛋白质降解

Ryan P Wurz1, Huan Rui1, Ken Dellamaggiore1

  • 1Amgen Research, Amgen Inc., Thousand Oaks, CA, USA.

Nature communications
|July 13, 2023
PubMed
概括

针对蛋白解酶的嵌合体 (PROTACs) 通过劫持无素-蛋白酶体系统,提供了新的治疗方法. PROTACs的结合亲和力和合作力与降解强度有很强的相关性,这使得有效的蛋白质降解剂的预测性设计成为可能.

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