对感冒疼痛的非动态反应反映了1型糖尿病和多神经病症中的dysautonomia
Thomas Arendt Nielsen1,2,3, Søren Lundbye-Christensen1,4, Yoanna Krasimirova Dimitrova3
1Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Scientific reports
|July 13, 2023
概括
在1型糖尿病 (T1DM) 患者的心脏自主神经病变 (CAN) 在感冒疼痛期间使用心率变化 (HRV) 进行评估. T1DM患者的HRV反应减少,表明自主功能受损和心血管风险增加.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 内分泌学 在内分泌学.
背景情况:
- 心脏自主神经病变 (CAN) 是长期糖尿病的常见并发症,通常使用心率变化 (HRV) 进行评估.
- 在压力期间评估HRV动态,如感冒疼痛,可能会在1型糖尿病 (T1DM) 中揭示亚临床CAN.
研究的目的:
- 通过分析HRV动态来调查性感冒疼痛暴露是否可以揭露T1DM患者的CAN.
- 为了比较T1DM患有远距离对称多神经病变的患者对感冒疼痛的HRV反应与健康对照.
主要方法:
- 在48名T1DM患者和21名健康对照中收集了24小时心电图 (ECG) 用于HRV分析.
- 在120秒的冷压器测试 (将手浸入2°C水中) 中利用了超短时间的HRV记录.
- 分析了交感和副交感HRV组件 (例如RMSSD,LF) 并与QRISK3得分相关联.
主要成果:
- 与对照组相比,T1DM患者的整体24小时HRV测量显著降低,证实了dysautonomia.
- 在T1DM患者中,暴露于感冒疼痛导致了交感和非动态的副交感HRV反应的减少.
- 与对照人群相比,T1DM患者对感冒疼痛的HRV反应显著降低 (4%对20%) 和同情 (11%对73%).
- 在T1DM患者中,QRISK3得分与24小时和超短时间HRV测量均有负相关性.
结论:
- 性感冒疼痛有效地揭示了T1DM患者的同情血管反应减弱,其特点是缺少的副同情和同情适应能力.
- 这种T1DM中神经心脏调节受损对平稳状态构成威胁,并与心血管疾病风险增加有关.
- 这些发现强调了在压力期间评估HRV动态的临床相关性,以早期检测和管理T1DM中CAN.
相关概念视频
Disorders of the Autonomic Nervous System
711
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
Raynaud's disease, also known as Raynaud's...
711
Responses to Heat and Cold Stress
13.6K
Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
13.6K
Thermosensation
30.5K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
30.5K
Local Anesthetics: Differential Sensitivity of Nerve Fibers
873
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
873
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
17
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
17
Nociception
28.0K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
28.0K


