环境对脊椎动物尿道进化的影响
1Department of Urology, SUNY Upstate Medical University, Syracuse, NY, USA. wienersc@upstate.edu.
Nature reviews. Urology
|July 13, 2023
概括
脊椎动物的泌尿系统进化适应了各种环境,推动了功能在调和酸平衡方面的创新. 了解这一进化过程,可以让我们深入了解脏生理学和临床泌尿学.
科学领域:
- 比较生理学比较生理学
- 进化生物学是进化的生物学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 脊椎动物尿道系统的进化是由环境压力所塑造的,其机制尚不完全理解.
- 尿道进化研究在儿科泌尿病学,生殖医学和尿病中具有临床意义.
研究的目的:
- 探索脏片段和泌尿器官的进化框架.
- 了解选择性压力如何影响脏生理学的发展.
主要方法:
- 在脊椎动物种群中对泌尿系统结构和功能进行比较分析.
- 追踪透调节和酸平衡机制的演变.
主要成果:
- 高度保存的淋巴细胞和靠近管管的功能有助于溶液的保留和排泄.
- 尿素在大型生物体中演变为盐度和溶液调节的关键透媒介.
- 酸调节从转移到皮肤/脏 (两动物),然后到鼻腺和后机制 (爬行动物/鸟类),最后到哺乳动物的高度缩的尿液生产.
结论:
- 进化背景对于理解脏生理学至关重要.
- 尿道系统的适应反映了从水生生物向陆生生物的转变以及不同的环境需求.
- 来自进化的见解可以为临床泌尿病学实践提供信息.
相关概念视频
Physiology of the Genitourinary System III: Urine Concentration and Dilution
23
The kidneys concentrate or dilute urine to maintain water and electrolyte balance. Nephrons, particularly the loop of Henle, play a crucial role in this process through the countercurrent multiplication system. This system establishes a high osmolarity in the renal medulla, which is essential for water reabsorption. In the loop of Henle’s descending limb, water is reabsorbed into the surrounding medulla due to its permeability to water. In contrast, the ascending limb actively transports...
23
Anatomy of the Genitourinary System II: Bladder and Urethra
138
The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
138
Disorders of the Urinary System
376
The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
376
Introduction to Urinary System
3.3K
The urinary system consists of two kidneys, two ureters, the urinary bladder, and the urethra.
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...
3.3K
Physiology of Urine Formation
4.9K
Urine formation is an essential function of the human body. It plays a critical role in maintaining homeostasis by regulating the volume and composition of body fluids. The kidneys, the primary organs involved in this process, filter blood to remove waste products and excess substances, ultimately producing urine.
Glomerular Filtration
The first stage in urine formation is glomerular filtration. Each kidney contains approximately 1 million nephrons, the functional units of filtration, with a...
Glomerular Filtration
The first stage in urine formation is glomerular filtration. Each kidney contains approximately 1 million nephrons, the functional units of filtration, with a...
4.9K
Anatomy of the Genitourinary System I: Kidneys and Ureters
46
The upper urinary system comprises two kidneys and two ureters, which are crucial in filtering blood and forming urine.KidneysLocation and Structure:The kidneys are two bean-shaped organs positioned behind the peritoneum on either side of the spine.Kidneys are between the 12th thoracic (T12) and the 3rd lumbar (L3) vertebrae.The position of the liver causes the right kidney to sit slightly lower than the left.Protective Layers:Each kidney is enveloped in a tough, fibrous membrane called the...
46


