使用温度来分析基于时间的决策的神经基础
Tiago Monteiro1,2, Filipe S Rodrigues1, Margarida Pexirra1,3
1Neuroscience Programme, Champalimaud Foundation, Lisbon, Portugal.
Nature neuroscience
|July 13, 2023
概括
温度变化会改变状腺 (基底腺) 神经活动,影响时间判断,但不影响运动速度. 这表明条状时间决定了决策的速度,而不是运动控制.
科学领域:
- 神经科学是一个神经科学.
- 决策 - 决策 - 决策 - 决策
- 发动机控制器的控制器
背景情况:
- 基底,特别是状体,对于决策和运动控制至关重要.
- 状神经群活动编码了对这些功能至关重要的时间信息.
- 一个关键的辩论是,条纹活动是否反映了决策过程或运动动力学.
研究的目的:
- 调查状人群活动动态在时间依赖行为中的作用.
- 区分条纹活动对决策与运动控制的影响.
- 在一个时间任务中检查温度对条纹活动和老鼠行为的影响.
主要方法:
- 在不同温度下测量了小鼠的条形状群体活动和行为反应.
- 将温度对神经活动和行为的影响与来自时间分类任务的数据进行比较.
- 分析了冷却和变暖如何影响神经模式和判断时间.
主要成果:
- 温度操纵 (冷却/温暖) 改变了条状神经活动模式和时间判断时间.
- 这些由温度引起的变化模仿了与决策相关的条纹活动的内生变异性.
- 最重要的是,温度没有显著影响运动动力学,将其与决策时间脱而出.
结论:
- 条形人群活动的时间动态直接影响潜伏决策过程的速度.
- 状活动主要指导选择选择速度,而不是连续的运动控制执行.
- 神经群活动的时间缩放是一个基本的神经机制,是行为时间变化的基础.
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