相关实验视频
Updated: Jul 23, 2025
08:50
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
16.3K
在脏和心血管疾病的交叉点FGF23和klotho
Daniel Edmonston1,2, Alexander Grabner1, Myles Wolf3,4
1Division of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Nature reviews. Cardiology
|July 14, 2023
概括
心血管疾病是慢性病 (CKD) 的主要风险之一. 在CKD中,纤维细胞生长因子23 (FGF23) 和低克洛托导致心脏问题,需要对矿物质失衡进行整体治疗.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
背景情况:
- 心血管疾病 (CVD) 是慢性病 (CKD) 患者的主要死亡原因.
- 慢性瘤的进展会通过慢性瘤特异性因素 (如 mineral homeostasis 失调) 加剧心血管疾病的风险.
- 纤维细胞生长因子23 (FGF23) 和klotho是矿物平衡的关键调节者,影响心血管健康.
研究的目的:
- 探索FGF23和klotho在CKD心血管并发症中的作用.
- 调查FGF23过量和klotho缺乏促进心脏功能障碍的机制.
- 评估向矿物质平衡的潜力,以改善CKD中的心血管结果.
主要方法:
- 对CKD相关心血管疾病中FGF23和klotho的新兴数据的审查.
- 分析FGF23,klotho和矿物代谢之间的相互作用.
- 讨论对治疗慢性脏病中心血管风险的临床影响.
主要成果:
- 随着FGF23的上升和CKD中klotho的下降,导致了klotho独立的,有害的心脏影响,包括左心室缩和心力衰竭.
- 溶性克洛托可以通过各种机制提供保护性心血管益处.
- 由于FGF23和klotho之间存在复杂的反循环,因此很难将病理的主要驱动因素分离出来.
结论:
- 针对整体地针对 mineral homeostasis 的疾病,对于改善 CKD 患者的心血管结果至关重要.
- 随机试验应侧重于解决矿物质不平衡的实际干预措施.
- 需要进一步的研究,以充分阐明FGF23和klotho在CKD的不同心血管并发症中的特定作用.
相关概念视频
01:24Chronic Kidney Disease II: Clinical Manifestations
35
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
35
01:25Chronic Kidney Disease I: Introduction
41
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage kidney disease (ESKD). At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate...
41
01:28Chronic Kidney Disease III: Interprofessional Care
43
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
43
01:29Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration
39
The kidneys are vital organs responsible for regulating blood filtration, waste excretion, and fluid balance, all of which are crucial for maintaining homeostasis. Renal physiology examines renal blood flow, glomerular filtration, and urine formation, ensuring the body’s internal environment remains stable.Renal Blood FlowThe kidneys receive about 20-25% of the cardiac output, typically around 1200 mL of blood per minute in an average adult. Blood flows into the kidneys through the renal...
39
01:29Acute Kidney Injury II: Pathophysiology
34
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
34
01:28Glomerular Filtration Rate and its Regulation
3.0K
The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
3.0K