婴儿的肠道微生物群组成和功能在生命早期的差异增加了发展自闭症谱系障碍的可能性
Simone Zuffa1, Patrick Schimmel2, Ayoze Gonzalez-Santana3
1Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, SW7 2AZ, UK.
Translational psychiatry
|July 14, 2023
概括
患有自闭症谱系障碍 (ASD) 的可能性较高的婴儿早期表现出肠道微生物群的差异,包括较低的Bifidobacterium和改变的GABA水平,先于行为变化. 这些肠道变化可能会影响以后的神经发育.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 发展心理学 发展心理学
背景情况:
- 肠-大脑轴和微生物群越来越多地与自闭症谱系障碍 (ASD) 神经生物学有关.
- 早期的肠道微生物组变化可能会在ASD的行为症状之前发生.
研究的目的:
- 为了研究具有或没有ASD家族病史的婴儿的纵向便微生物群和代谢组概况.
- 将肠道微生物组和代谢组数据与早期发育评估相关联.
主要方法:
- 从出生到36个月的婴儿 (n=16个高概率的ASD,n=19个低概率) 的前性纵向研究.
- 便微生物群和非向的代谢组概况.
- 使用穆伦早期学习量表 (MSEL) 和自闭症诊断观察时间表 (ADOS-2) 的发育评估.
主要成果:
- 在5个月时,患ASD (EL) 可能性较高的婴儿的Bifidobacterium数量减少,Clostridium/Klebsiella数量增加,相比于患ASD (EL) 可能性较低的婴儿.
- 5个月后,LL婴儿的便GABA含量较高,随着年龄的增长而下降;EL婴儿的GABA含量始终较低.
- 微生物组-代谢组分析显示GABA与Bifidobacterium之间的积极关联,以及与Clostridium的负面关联.
结论:
- 早期的肠道微生物群组成和功能在婴儿中发生变化,患ASD的可能性增加.
- 这些肠道变化发生在可检测的行为障碍之前,这表明在后来的神经发育变异性中可能发挥作用.
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