在服用SSRI药物的同时服用患者中,用于治疗耐药性抑郁症的psilocybin
Guy M Goodwin1, Megan Croal2, David Feifel3
1COMPASS Pathfinder Ltd, London, United Kingdom. guy.goodwin@compasspathways.com.
概括
这项研究探讨了治疗耐药性抑郁症 (TRD) 的SSRI与psilocybin (COMP360) 的结合. 结果显示,抑郁症显著减少和耐受性,这表明了潜在的新治疗范式.
科学领域:
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 耐治疗抑郁症 (TRD) 是一个重大的临床挑战.
- 目前的治疗方法往往需要抗抑郁药的戒断,这可能是有问题的.
- 西正在研究其潜在的抗抑郁作用.
研究的目的:
- 为了探索合成西 (COMP360) 的安全性,耐受性和疗效,作为选择性血清素再吸收抑制剂 (SSRI) 的辅助剂,在TRD的成年人中.
- 评估psilocybin对抑郁症症状严重性的影响.
- 评估治疗出现的不良事件 (TEAE) 和临床结果.
主要方法:
- 一个国际,固定的剂量,开放的标签,第二阶段的探索性研究.
- 19名TRD患者接受了单次25毫克的西剂,并得到了心理支持.
- 随访时间为3周,通过蒙哥马利-阿斯伯格抑郁评分表 (MADRS) 和临床全球印象严重性 (CGI-S) 评分来评估疗效.
主要成果:
- 在第3周,MADRS总分比基线平均减少了-14.9分.
- 在CGI-S得分的显著改善,与基线平均变化为-1.3.
- 42.1%的参与者实现了反应和缓解标准.
- 大多数治疗出现的不良事件 (TEAE) 是轻微的和短暂的,没有报告严重事件或增加自杀念头.
结论:
- 作为SSRI的辅助剂,松素 (COMP360) 在患有TRD的成年人中显示出有前途的疗效和耐受性.
- 这些发现支持在更大规模的受控试验中进一步调查,特别是对于无法停止抗抑郁药物治疗的患者.
- 这种方法可能为TRD提供一种新的治疗策略,可能避免有问题的抗抑郁药物戒断.
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