恩特罗拉克和特拉贝克丁通过上调THBS1来协同抑制上皮卵巢癌

恩特罗拉克和特拉贝克丁通过上调THBS1来协同抑制上皮卵巢癌

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Zheng Zeng^1,2,3,4, Caiji Lin^1,2, Meng-Chun Zhang^1,2

¹Genomics Research Center, Key Laboratory of Gut Microbiota and Pharmacogenomics of Heilongjiang Province, State-Province Key Laboratory of Biomedicine-Pharmaceutics of China, College of Pharmacy, Harbin Medical University, Harbin, China.

Phytotherapy research : PTR

|July 14, 2023

概括

乳 (ENL) 和特拉贝克丁 (Trabe) 通过抑制血管生成,协同抑制上皮卵巢癌 (EOC). 血栓素1 (THBS1) 过度表达增强了这些联合的抗癌效应,提供了一个有前途的治疗策略.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
药理学药理学是指药理学的学科.

背景情况:

表皮卵巢癌 (EOC) 是癌症相关死亡的主要原因,治疗选择有限.
乳 (ENL) 和特拉贝克丁 (Trabe) 已显示出对EOC的个别有效性.
在ENL和Trabe介导的EOC抑制中,Thrombospondin 1 (THBS1) 的作用尚未被探索.

研究的目的:

调查ENL和Trabe对EOC的联合抑制作用.
确定THBS1在ENL和Trabe的抗癌活动中的参与.
评估ENL和Trabe组合的治疗潜力,有或没有THBS1调制.

主要方法:

EOC细胞系 (ES-2) 感染过度表达的THBS1.1.
试管培养试验以评估抗血管生成.
在药物干预研究中体内外移植裸体小鼠模型.
用于微生物群分析的16S rDNA测序.

主要成果:

恩尔和特拉贝表现出对EOC细胞增殖和迁移的协同抑制.
结合ENL和Trabe抑制了血管生成,THBS1过度表达放大了这种效应.
观察到TIMP3和CD36的上调,以及MMP9,VEGF和CD47的下调.
在体内研究证实了药物组合的优异瘤生长抑制,THBS1.1进一步增强了THBS1.

结论:

恩尔和特拉贝证明了对EOC的协同抗癌活性.
THBS1在促进ENL和Trabe的联合治疗效果方面发挥着至关重要的作用.
这种可能由THBS1调节的组合疗法是EOC治疗的有希望的策略.

关键词:

在THBS1中,THBS1是THBS1.中乳酸盐是什么中乳酸盐是什么上皮卵巢癌卵巢癌卵巢癌有协同作用的抗癌效应.在trabectedin中进行了追踪

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