患有COVID-19的超重/肥胖脏移植患者的氧气需求:一项观察性队列研究
Alexandre Veronese-Araújo1, Débora D de Lucena1,2, Isabella Aguiar-Brito1
1Department of Medicine, Nephrology Division, Federal University of São Paulo, São Paulo 04038-031, SP, Brazil.
Diagnostics (Basel, Switzerland)
|July 14, 2023
概括
患有COVID-19的超重或肥胖移植接受者需要更多的氧气. 这种风险在老年人中更高,吸烟患者的功能较差,这表明需要早期风险分层.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
- 心脏代谢健康状况
背景情况:
- 肥胖是心脏代谢综合征的一个组成部分,增加了COVID-19的严重程度.
- 免疫抑制群体,如移植接受者 (KTRs),面临 COVID-19 的风险增加.
- 肥胖和脏移植对COVID-19氧气需求的综合影响尚未完全理解.
研究的目的:
- 调查COVID-19脏移植接受者的超重/肥胖和氧气需求之间的关联.
- 在这个特定的患者群体中确定增加氧气需求的风险因素.
主要方法:
- 对284名被诊断患有COVID-19的移植接受者 (KTR) 的回顾性分析.
- 2020年3月至2020年8月期间在一个单一中心收集的数据.
- 统计分析以确定氧气需求的风险因素,重点是身体质量指数 (BMI).
主要成果:
- 超过65%的KTRs的BMI表明超重或肥胖.
- 更高的BMI是氧气需求的一个独立风险因素 (OR = 1.07,p = 0.02).
- 需要氧气的超重/肥胖的KTR通常是老年人,吸烟者,较高的LDH,较低的eGFR,淋巴细胞和水平.
结论:
- 超重/肥胖与COVID-19的KTR中氧气需求增加有关.
- 高龄化和吸烟加剧了超重/肥胖的KTRs的氧气需求.
- 这些因素的早期识别有助于在移植后的COVID-19患者的风险分层和治疗决策.
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