基于呼吸系统症状和X光学发现的阿哈拉西亚亚型差异
Jelena Jankovic1,2, Branislava Milenkovic1,2, Ognjan Skrobic2,3
1Clinic for Pulmonology, University Clinical Center of Serbia, 11000 Belgrade, Serbia.
Diagnostics (Basel, Switzerland)
|July 14, 2023
概括
阿哈拉西亚亚型会影响呼吸系统症状和肺部问题. 更大的食道直径与慢性肺部变化相关,有助于早期诊断和治疗.
科学领域:
- 胃肠病学和肺病学 胃肠病学和肺病学
- 放射学和成像学 放射学和成像学
背景情况:
- 阿哈拉西亚是一种罕见的食道运动障碍,呈现出三种人数学亚型.
- 呼吸道症状和肺部并发症是由于食道压缩或吸收的阿喀拉西亚患者常见的.
- 之前的研究表明,症状呈现在性别之间有所不同,不论是阿喀拉西亚亚型.
研究的目的:
- 为了研究秋症亚型,食道直径和呼吸系统症状的发生之间的关系.
- 分析阿喀拉西亚患者的放射性肺部发现及其与食道直径和阿喀拉西亚类型的相关性.
主要方法:
- 对114名阿喀拉西亚患者的回顾性分析.
- 消化管测量仪用于分类阿喀拉西亚亚型.
- 症状评分 (SS) 和CT扫描以评估呼吸系统症状和肺病理.
- 食道直径,阿卡拉西亚亚型和肺部变化之间的相关性分析.
主要成果:
- 48%的患者报告呼吸系统症状;所有患者都有胃肠道症状.
- 症状评分 (SS) 预测了亚型1 (AUC=0.318) 和亚型2 (AUC=0.626).
- 第2亚型是最常见的 (50.8%);第3亚型的食道直径最大 (5.8厘米).
- 在亚型1和3,以及亚型2和3之间发现了食道直径的显著差异 (p=0.011).
- 51.7%的患者在CT扫描上显示肺部变化,食道直径较高与慢性变化相关 (p<0.001).
- 更高的食道直径与GGO,结节变化和纤维化 (p<0.001) 等对体肺部变化相关.
结论:
- 虽然阿喀拉西亚亚型表现出类似的呼吸系统症状,但症状评分 (SS) 可以帮助预测1和2亚型.
- 增加的食道直径是与慢性结构性肺部变化相关的重要因素.
- 早期识别阿喀拉西亚和肺部异常之间的联系对于及时诊断和管理至关重要.
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