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血红蛋白和内毒素水平预测了酒精性肝硬化患者的萨科佩尼亚发生情况

Akihiko Shibamoto¹, Tadashi Namisaki¹, Junya Suzuki¹

¹Department of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.

Diagnostics (Basel, Switzerland)

|July 14, 2023

概括

血红蛋白 (Hb) 水平可以预测肝硬化 (LC) 患者的肉症. 将Hb与内毒素活性 (EA) 结合使用可能会改善酒精性肝硬化 (AC) 患者的预测.

科学领域:

肝病学肝病学是一种肝病学.
老年病的医生老年病的医生
临床营养学临床营养学

背景情况:

酒精是肝硬化的主要危险因素.
麻症是LC患者常见的并发症,影响预后.
识别可靠的代孕标志物对于LC中的sarcopenia至关重要.

研究的目的:

在肝硬化患者中识别了缩症的替代标记物.
为了比较酒精性肝硬化 (AC) 和非酒精性肝硬化 (NAC) 患者之间的sarcopenia风险因素.
为了评估血红蛋白 (Hb) 和内毒素活性 (EA) 的预测性表现.

主要方法:

在451名LC患者 (149名AC,302名NAC) 中评估了手握强度和骨肌肉质量.
使用EA测定测量了内毒素活性 (EA) 水平.
分析了麻症的风险因素和Hb和EA的预测准确性.

主要成果:

萨科佩尼亚的危险因素包括年龄,性别,疾病严重程度 (CP-C LC),低Hb和EA升高.
在所有LC患者中,Hb水平预测了78.1%的准确性.
在AC患者中,Hb以83.6%的准确度预测了肉症,通过与EA结合而改善.

结论:

血红蛋白 (Hb) 是肝硬化 (LC) 中的潜在预测因子.
内毒素活性 (EA) 可能增强酒精性肝硬化 (AC) 中的萨科佩尼亚预测.
需要进一步的研究来验证这些标志物在不同的LC群体中的有效性.

关键词:

酒精性肝硬化酒精性肝硬化内毒素活性测定试验.血红蛋白血红蛋白是一个没有酒精的肝硬化.这种类型的麻症是sarcopenia.

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