药物相关的胃病:诊断标准
Dmitry S Bordin1,2,3, Maria A Livzan4, Olga V Gaus4
1A.S. Loginov Moscow Clinical Scientific Center, Department of Pancreatic, Biliary and Upper Digestive Tract Disorders, 111123 Moscow, Russia.
Diagnostics (Basel, Switzerland)
|July 14, 2023
概括
药物诱导的胃是一种常见的担忧,各种药物会导致胃损伤. 了解这些风险对于及时预防和识别不良事件至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
- 内部医学 内部医学
背景情况:
- 药物不良反应,特别是在胃肠道,是常见的,可以从轻微到危及生命的范围.
- 胃损伤可能是由于口服和肠道内服药物造成的.
- 了解药物诱导的胃损伤对于患者的安全和治疗坚持是必不可少的.
研究的目的:
- 审查药物诱导的胃损伤的机制,危险因素和临床特征.
- 讨论通常与胃损伤相关的特定药物,包括NSAID,阿司匹林,抗凝固剂,皮质类固醇,抗癌药物,口服铁和质子抑制剂.
- 突出显示新出现的胃肠道损伤区域来自新的疗法,如检查点抑制剂.
主要方法:
- 对药物诱导胃损伤的机制,危险因素和临床特征的文献综述.
- 分析与特定药物类别相关的内镜,组织病理和临床数据.
- 讨论共存疾病的影响,如Helicobacter pylori感染.
主要成果:
- 非类固醇抗炎药物 (NSAIDs) 和阿司匹林是已有充分研究的胃损伤原因,尽管它们通常因H. pylori而复杂化.
- 抗凝剂,皮质类固醇和口服铁制剂对胃的影响仍然存在争议.
- 新的抗癌药物,包括检查点抑制剂,代表了药物诱导的胃肠道损伤的日益严重的原因.
结论:
- 需要扩大对药物诱导的胃肠道损伤的理解.
- 及时识别和预防与药物相关的胃是非常重要的.
- 对新药毒性的进一步研究是有必要的.
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