缺血性中风后的睡眠呼吸障碍和预后:重要的不是呼吸暂停-呼吸暂停指数
Lyudmila Korostovtseva1, Mikhail Bochkarev1, Valeria Amelina1,2
1Almazov National Medical Research Centre, 197341 St. Petersburg, Russia.
Diagnostics (Basel, Switzerland)
|July 14, 2023
概括
睡眠呼吸障碍 (SDB) 指数,特别是低氧化负担,预测缺血性中风后的长期结果. 较高的氧气不足负担与减少生存时间和增加心血管事件有关.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 心脏病学 心脏病学
背景情况:
- 睡眠呼吸障碍 (SDB) 在中风后很常见,并与不良结果有关.
- 确定中风后预后的预测因素至关重要.
研究的目的:
- 评估夜间呼吸指数对缺血性中风患者临床结果的影响.
- 确定SDB参数是否预测死亡率和非致命心血管事件.
主要方法:
- 在发作后24小时内对328名缺血性中风患者进行观察研究.
- 睡眠测谎仪在入院后72小时内进行.
- 通过累积终点分析和考克斯回归来评估长期结果.
主要成果:
- 较高的低氧化负担 (SpO2 < 90%的时间) 与显著较低的生存时间相关.
- 阻塞性呼吸暂停-呼吸暂停指数 (AHI) 并没有显著预测生存率.
- 低氧化负担独立预测的生存率,无论中风的严重程度或并发症.
结论:
- 夜间低血负担是缺血性中风后长期结果的独立预测因素.
- 低血指数提供了超越传统风险因素的额外预后价值.
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