肠道微生物组在多发性硬化和相关疾病的发病过程中的作用
Anna Dunalska1, Kamila Saramak2, Natalia Szejko3,4
1Department of Neurology, Medical University of Warsaw, 02-097 Warsaw, Poland.
Cells
|July 14, 2023
概括
肠道微生物群在多发性硬化症 (MS) 和神经髓炎光学谱障碍 (NMO-SD) 病理生理学中发挥着关键作用. 涉及到特定的细菌,这表明微生物组调制是这些神经炎症疾病的潜在治疗策略.
科学领域:
- 神经免疫学 神经免疫学
- 微生物组研究 微生物组研究
- 神经学 神经学
背景情况:
- 多发性硬化症 (MS) 是一种慢性,进展性神经炎症性疾病,受遗传,免疫和环境因素的影响.
- 人们越来越认识到肠-大脑轴在神经疾病,包括神经炎症疾病中的作用.
- 新出现的证据突出显示了肠道微生物组参与MS和相关疾病的病理生理学.
研究的目的:
- 系统地审查当前关于肠道微生物组在MS和神经omyelitis optica谱系障碍 (NMO-SD) 病理生理学中的作用的证据.
- 确定与MS和NMO-SD相关的特定细菌属.
- 探索针对MS和NMO-SD的微生物组向疗法的潜力.
主要方法:
- 在Medline,Pubmed和Scopus索引的研究的系统文献综述.
- 对在MS和NMO-SD中研究肠道微生物组的研究分析.
- 鉴定涉及疾病发病的细菌物种和属.
主要成果:
- 几种细菌属,包括* 伪 *, * 菌 *, * 血 *, * 蓝 *, * 多雷亚 *, * 菌 *, * 甲 菌 *, * 阿克尔曼西亚 *, * 德苏尔福维布里奥纳ceae *, 与MS病理生理学有关.
- *Clostridium perfringens*和*Streptococcus*已经与NMO-SD的病理生理学有关.
- 初步数据表明,益生菌和其他微生物组调节剂可能为MS/NMO-SD提供治疗益处.
结论:
- 肠道微生物组是MS和NMO-SD病理生理学的重要因素.
- 特定的肠道细菌可以作为疾病发展和进展的生物标志物.
- 准肠道微生物组为MS和NMO-SD的新型疾病修饰疗法提供了一个有希望的途径.
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