马类克罗夫顿杂草 (Ageratina spp.) 是一种常见的杂草. 肺毒性:我们知道什么,我们需要知道什么?
Frances Marie Shapter1, José Luis Granados-Soler1, Allison J Stewart1
1School of Veterinary Science, University of Queensland Gatton, 5391 Warrego Highway, Gatton, QLD 4343, Australia.
Animals : an open access journal from MDPI
|July 14, 2023
概括
克罗夫顿杂草 (Ageratina adenophora) 会对马造成严重的,不可逆转的肺损伤. 本次审查强调了需要了解物种特异性毒性,以开发对这种侵入性植物中毒的治疗方法.
科学领域:
- 兽医毒理学 兽医毒理学
- 植物科学 植物科学
- 马类医学 马类医学
背景情况:
- 克罗夫顿杂草 (Ageratina adenophora) 是一种高度入侵的植物,在马中引起严重的呼吸系统疾病.
- 克罗夫顿杂草对马的肺毒性在澳大利亚和新西兰得到了充分证实,但在全球范围内可能被诊断不足.
- 在动物模型 (动物,子,山羊) 中对克罗夫顿杂草毒性病原体的现有研究表明,器官选择性与马明显不同.
研究的目的:
- 审查可用的关于由克罗夫顿杂草引起的马类毒性的文献.
- 为了比较Crofton杂草毒性的病变发生在马和其他动物物种.
- 确定知识上的差距,并提出未来的研究方向,用于马类Crofton杂草中毒.
主要方法:
- 对Crofton杂草和马匹健康的毒理和暴露数据的文献综述.
- 对不同动物物种的已发表的致病研究进行比较分析.
- 综合信息以确定毒性和生物转化中的特定物种变异.
主要成果:
- 克罗夫顿杂草毒性的病原发生在动物物种之间有很大差异,与马匹的临床和实验发现不同.
- 特定物种对植物毒素的敏感性,机械毒性过程和毒素生物转化/生物激活是变化的关键来源.
- 需要识别特定于马的毒素并了解独特的生物转化途径.
结论:
- 了解特定物种的毒性机制对于解决马匹的克罗夫顿杂草中毒至关重要.
- 需要进一步的研究来识别特定的毒素,并制定有效的预防和治疗策略,以治疗马类Crofton杂草的毒性.
- 准确的诊断和管理克罗夫顿杂草的毒性需要区分它从其他马的呼吸系统疾病,特别是在特有地区.
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