患者报告的肝癌和胃肠癌随机对照试验的结果
Carolin Winkelmann1,2, Anna Mezentseva1, Bodo Vogt1,2,3
1Chair in Empirical Economics, Otto-von-Guericke-University Magdeburg, Universitätsplatz 2, 39106 Magdeburg, Germany.
概括
患者报告的结果测量 (PROM) 在癌症试验中越来越重要. 然而,用于肝癌和胃肠癌的随机对照试验 (RCT) 往往缺乏全面的生活质量评估,限制了整体的患者观点.
科学领域:
- 在瘤学瘤学.
- 临床试验 临床试验
- 健康 结果 研究 研究 结果
背景情况:
- 从历史上看,瘤治疗的有效性是使用死亡率和发病率指标来评估的.
- 患者报告的结果指标 (PROM) 将重点转移到更广泛的健康和生活满意度概念.
- 本研究研究了PROM在肝脏和胃肠道随机对照试验 (RCT) 中的使用情况.
研究的目的:
- 评估PROMs在肝癌和胃肠癌RCT中的整合和利用情况.
- 在这个特定的试验人群中识别常用的PROM.
- 评估癌症RCT中生活质量指标的综合性和权重.
主要方法:
- 进行了对43项随机对照试验 (RCT) 进行的肝脏或胃肠道癌症干预的系统审查.
- 如果这些研究报告了与健康相关的生活质量指标作为主要或次要结果,则将其纳入.
- 分析了使用的PROM频率和类型.
主要成果:
- 欧洲癌症研究和治疗组织 (EORTC QLQ-C30) 的生活质量调查问卷是最常用的PROM.
- 特定的PROM如EORTC QLQ-STO22 (胃肠道) 和简式36/EORTC QLQ-HCC18 (肝脏) 也是常见的.
- 生活质量措施往往是次要的结果,没有全面整合.
结论:
- 肝脏和胃肠道瘤学的随机对照试验 (RCT) 经常缺乏彻底的生活质量评估.
- 患者报告的结果往往被降为次要地位,阻碍了完整的患者视角.
- 加强PROM的整合和优先考虑对于全面评估癌症治疗至关重要.
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