用不同类型的阿斯伯吉勒斯生产的阿马扎克对肠道屏障和微生物群的影响
Hironobu Nakano1, Sho Setoguchi2, Kuniaki Kawano2
1The United Graduate School of Agricultural Sciences, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan.
Foods (Basel, Switzerland)
|July 14, 2023
概括
一种发酵饮料Black koji Amazake可以增强小鼠的肠道屏障功能和抗氧化防御. 这种传统的日本饮料通过减少肠道炎症和内毒素水平,显示出预防炎症性肠病的潜力.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 炎症性肠病 (IBD) 是一种慢性胃肠道疾病.
- 饮食干预措施正在探索IBD预防.
- 肠道屏障功能障碍是IBD病变发生的一个关键因素.
研究的目的:
- 评估日本传统发酵饮料Amazake对肠道屏障功能的预防作用.
- 为了比较黑科吉亚马扎克 (BA) 和黄色科吉亚马扎克 (YA) 对肠道健康的影响.
- 研究Amazake对肠道微生物群和炎症标志物的影响.
主要方法:
- 两种类型的Amazake (BA和YA) 被生产并分析了营养含量.
- 患有饮食引起的肠道屏障功能障碍的小鼠被用10%的BA或YA治疗了两个月.
- 用16S rRNA基因测序分析了肠道微生物组成.
- 测量了抗氧化因子 (Nrf2,HO1,SOD-2),肠道屏障蛋白 (occludin) 和便免疫球蛋白A (IgA) 的基因表达.
主要成果:
- 与YA相比,BA表现出较高水平的异多氧糖,酸和酸.
- BA显著上调抗氧化因子 (Nrf2,HO1,SOD-2) 和肠道屏障蛋白occludin.
- 便免疫球蛋白A (IgA) 水平被BA显著提高.
- 无论是BA和YA治疗都降低了血清内毒素和肝单细胞化疗蛋白-1 (MCP-1) 水平.
- BA增加了Lachnospiraceae的丰富性,而YA增加了肠道微生物群中的Akkermansia muciniphilia的丰富性.
结论:
- 黑科吉亚马扎克在保护肠道屏障功能方面表现出显著的潜力.
- BA的保护作用归因于其丰富的特定化合物含量和抗氧化途径的调节.
- 亚马扎克的消费可能有助于减少内毒素侵入和相关炎症,提供IBD预防的饮食策略.
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