Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Studying the Cytoskeleton01:17

Studying the Cytoskeleton

6.3K
The cytoskeletal architecture can be studied using different microscopic and biochemical techniques. Electron microscopy was instrumental in discovering the cytoskeletal architecture around the 1960s, which allowed obtaining structural information at a high-resolution level. However, the sample preparation procedure often limits this ability in biological samples. Several protocols have been developed over the years to optimize sample preparation. In one of the protocols known as rotary...
6.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Monoalcohol-Directed Shape Control in a Surfactant-Free Gold Nanoplate Synthesis.

Small methods·2026
Same author

Plasmonic Supercavitation Enables Nanoparticle Photo-Ejection Across Air/Water Interface.

Small science·2026
Same author

Local strain-engineering of exciton energy in 2D materials with nanoindentation.

Nanoscale·2026
Same author

Nondestructive Atomic Defect Quantification of Two-Dimensional Materials and Devices.

ACS applied materials & interfaces·2026
Same author

Mechanical compression induces neuronal apoptosis, reduces synaptic activity, and promotes glial neuroinflammation in mice and humans.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Wnt inhibition alleviates resistance to anti-PD1 therapy and improves antitumor immunity in glioblastoma.

Proceedings of the National Academy of Sciences of the United States of America·2025

相关实验视频

Updated: Jul 23, 2025

Measuring the Mechanical Properties of Living Cells Using Atomic Force Microscopy
08:41

Measuring the Mechanical Properties of Living Cells Using Atomic Force Microscopy

Published on: June 27, 2013

40.2K

原子力显微镜测量瘤机械性质的方法

Julian Najera1, Matthew R Rosenberger1, Meenal Datta1

  • 1Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.

Cancers
|July 14, 2023
PubMed
概括

原子力显微镜 (AFM) 提供了对生物组织机械性质的高分辨率洞察. 这篇评论探讨了AFM.

科学领域:

  • 生物物理学的生物物理.
  • 癌症研究 癌症研究
  • 材料科学 材料科学 材料科学

背景情况:

  • 原子力显微镜 (AFM) 对于评估生物材料的机械性质至关重要.
  • 癌症研究人员利用AFM将机械生物学与癌症发病,进展和治疗耐药性联系起来.
  • 以前的AFM研究主要集中在细胞纳米机理上,忽视了瘤和宿主器官的复杂性.

研究的目的:

  • 审查AFM纳米印记在组织力学中的原理和应用.
  • 要突出使用AFM在组织分析中的关键考虑因素.
  • 检查AFM在特征癌症组织机制及其临床潜力的作用.

主要方法:

  • 解释了AFM纳米冲刺原理用于组织力学.
  • 讨论AFM技术应用和组织样本准备的关键考虑.
  • 审查了AFM在癌症组织机械性质表征中的应用.

主要成果:

  • AFM使生物材料机械性能能够进行高分辨率的评估.
  • 描述组织尺度机制为癌症机制病理学提供了新的见解.
  • AFM的应用正在扩大,超越了细胞的范围,进入了组织水平的癌症研究.
关键词:
扬格的模块是这样的:癌症机械病理学 癌症机械病理学机械生物标志物 机械生物标志物纳米机械签名 纳米机械签名硬性 硬性 硬性粘性弹性 粘性弹性

更多相关视频

Micro-Mechanical Characterization of Lung Tissue Using Atomic Force Microscopy
11:10

Micro-Mechanical Characterization of Lung Tissue Using Atomic Force Microscopy

Published on: August 28, 2011

23.0K
Measurement of the Compressibility of Cell and Nucleus Based on Acoustofluidic Microdevice
09:06

Measurement of the Compressibility of Cell and Nucleus Based on Acoustofluidic Microdevice

Published on: July 14, 2022

1.7K

相关实验视频

Last Updated: Jul 23, 2025

Measuring the Mechanical Properties of Living Cells Using Atomic Force Microscopy
08:41

Measuring the Mechanical Properties of Living Cells Using Atomic Force Microscopy

Published on: June 27, 2013

40.2K
Micro-Mechanical Characterization of Lung Tissue Using Atomic Force Microscopy
11:10

Micro-Mechanical Characterization of Lung Tissue Using Atomic Force Microscopy

Published on: August 28, 2011

23.0K
Measurement of the Compressibility of Cell and Nucleus Based on Acoustofluidic Microdevice
09:06

Measurement of the Compressibility of Cell and Nucleus Based on Acoustofluidic Microdevice

Published on: July 14, 2022

1.7K

结论:

  • AFM是了解组织规模的癌症机械生物学的一个有价值的工具.
  • 使用AFM进行进一步的研究可以弥合机械生物学和临床癌症应用之间的差距.
  • 对于未来的瘤学临床诊断和治疗策略,AFM具有前景.