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微塑料可能是早期结肠直肠癌的驱动因素吗?

Shelley Li¹, Jacqueline I Keenan¹, Ian C Shaw²

¹Department of Surgery, University of Otago Christchurch, Christchurch 8011, New Zealand.

|July 14, 2023

概括

上升的早期结直肠癌 (EOCRC) 可能与微塑料 (MP) 有关. MPs可能会破坏结肠中的保护性粘液层,增加癌症风险. 需要进一步的研究来证实这种环境驱动因素.

科学领域:

胃肠道学和环境健康

背景情况:

早期结肠直肠癌 (EOCRC) 的发病率在全球范围内不断上升,特别是在偏远的结肠和直肠.
这一趋势表明自1960年以来的队列效应,可能是由环境因素驱动的.
微塑料 (MP) 越来越普遍,并被人类消费.

研究的目的:

探索微塑料作为EOCRC日益增长的发病率的驱动力的潜在作用.
调查MP可能导致结直肠癌发展的机制.

主要方法:

对EOCRC流行病学,塑料污染和肠道生理学现有文献的审查.
探索微塑料和结肠粘液层之间的潜在生物相互作用.

主要成果:

微塑料与胃肠道相互作用,特别是结肠和直肠.
对于MP来说,存在潜在的机制来破坏保护性结肠粘液层.
粘液层的破坏可能会降低其保护作用,增加结直肠癌的风险.

结论:

EOCRC的增加与微塑料在环境中的存在增加一致.
微塑料可能会损害结肠粘液屏障,导致结肠直肠癌发生.
进一步调查MPs在结直肠癌发病过程中的作用是有必要的.

关键词:

结肠粘液层是一个结肠粘液层.结肠直肠癌是什么意思早期发病的结肠直肠癌是什么微塑料是微塑料中的一种.

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