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功能和代谢上不同的黑色素瘤相关的巨细胞起源于常见的骨髓前体

Gabriela A Pizzurro¹, Kate Bridges¹, Xiaodong Jiang²

¹Department of Biomedical Engineering, School of Engineering and Applied Science, Yale University, New Haven, CT 06511, USA.

|July 14, 2023

概括

黑色素瘤中的瘤相关巨细胞 (TAMs) 主要来自骨髓,而不是皮肤. 了解这些多样化的TAM为黑色素瘤治疗提供了新的治疗点.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
细胞生物学细胞生物学

背景情况:

瘤相关巨细胞 (TAMs) 是瘤微环境 (TME) 的关键调节者.
TAM异质性影响黑色素瘤的进展和患者的预后.
针对TAMs是一个潜在的黑色素瘤治疗策略.

研究的目的:

在临床相关的黑色素瘤模型 (YUMM1.7) 中研究TAMs的起源和动态.
在瘤进展过程中描述不同的TAM子集及其功能概况.
为了在黑色素瘤相关的巨细胞中确定潜在的治疗点.

主要方法:

在体内研究中使用了YUMM1.7黑色素瘤模型.
使用F4/80表达式来识别和排序TAM子集.
进行了多参数分析,RNA测序和基因组丰富分析 (GSEA).

主要成果:

确定了不同的F4/80表达的TAM子集,随着时间的推移,F4/80高分数的增加.
证明了黑色素瘤TAMs主要来自骨髓前体.
在具有明显的免疫抑制和代谢特征的TAM亚群中揭示了时间差异.

结论:

黑色素瘤TAM在很大程度上取决于骨髓起源.
不同的TAM子集表现出独特的转录和代谢特征.
这些发现为在黑色素瘤治疗中准免疫抑制性TAM提供了基础.

关键词:

免疫抑制是一种免疫抑制.巨细胞的本体发生.黑色素瘤是一种黑色素瘤.代谢途径代谢途径组织居民巨细胞.瘤微环境是一个微环境.与瘤相关的巨细胞.

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