免疫功能低下患者皮肤头部和部状和基底细胞癌的管理
Krishna K Bommakanti1,2, Nikitha Kosaraju3, Kenric Tam1,2
1Department of Head and Neck Surgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095-1624, USA.
Cancers
|July 14, 2023
概括
非黑色素瘤性皮肤癌 (NMSC) 正在增加,特别是在免疫功能低下的患者中. 本综述涵盖了NMSC的发病过程,免疫反应,以及这种高风险群体的新免疫疗法.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 在全球范围内,非黑色素瘤皮肤癌 (NMSC) 的发病率正在增加.
- 免疫功能低下的人面临患NMSC的风险要高得多.
- 早期检测和管理对于在免疫抑制患者中减少与NMSC相关的发病率和死亡率至关重要.
研究的目的:
- 审查头部和部皮肤状细胞癌 (SCC) 和基底细胞癌 (BCC) 在免疫受损患者的发病过程.
- 检查免疫系统在这种人群中NMSC进展中的作用.
- 详细介绍新型免疫疗法在免疫功能低下个体中对NMSC的应用和潜力.
主要方法:
- 文献综述和当前研究的综合.
- 对免疫受损人群中NMSC发病率的流行病学数据的分析.
- 对NMSC病变发生过程中的免疫反应机制研究的评估.
- 对NMSC免疫疗法的临床试验和案例研究的审查.
主要成果:
- 免疫受损状态是NMSC发展和进展的重要风险因素.
- 在这些患者中,特定的免疫路径与SCC和BCC的发病有关.
- 新兴的免疫疗法对免疫功能低下个体的NMSC治疗有前途,尽管需要进一步的研究.
结论:
- 涉及预防,监测和早期干预的综合方法对于在免疫受损患者中管理NMSC至关重要.
- 了解免疫反应是开发向治疗的关键.
- 新型免疫疗法是改善这一脆弱患者群体治疗结果的有希望的途径.
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