高风险性行为是口腔癌的危险因素吗?
Gunnar Wichmann1,2, Jasmin Rudolph1, Sylvia Henger2,3
1Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Leipzig, Liebigstr. 10-14, 04103 Leipzig, Germany.
Cancers
|July 14, 2023
概括
这项研究在德国人口中没有发现高风险性行为 (HR-SB) 与口腔状细胞癌 (OPSCC) 之间的联系. 结果与北美研究不同,表明HR-SB单独可能不会增加OPSCC风险.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 有证据表明,高风险性行为 (HR-SB) 和人类乳头瘤病毒 (HPV) 与口腔状细胞癌 (OPSCC) 有关.
- 之前的一项研究确定HR-SB是OPSCC的风险因素,但需要复制.
研究的目的:
- 在德国人口中调查HR-SB和OPSCC之间的关联.
- 复制或反驳北美关于HR-SB和OPSCC风险的研究结果.
主要方法:
- 一项涉及OPSCC患者和倾向分数 (PS) 的嵌套病例控制研究与德国队列的健康对照进行了匹配.
- 采访和问卷评估了HR-SB,烟草吸烟和酒精消费.
- 统计分析包括千二测试和后勤回归.
主要成果:
- 在患者和对照者之间,PS匹配减少了年龄,性别,吸烟和酒精消费的基线差异.
- OPSCC患者报告说,他们早些时候进行了第一次性交,但没有显示与HR-SB的关联.
- 没有发现OPSCC与口交,性伴侣数量,随意性行为或性传播疾病之间的联系.
结论:
- 该研究发现,在德国OPSCC患者中,HR-SB的患病率很低,这与一些北美研究结果相矛盾.
- 仅HR-SB本身可能不是在这个人群中发展OPSCC的重要风险因素.
- 关于HR-SB和OPSCC风险的欧洲和北美研究结果似乎不一致.
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