外部应用的电磁场和高温会对癌细胞造成不可逆转的损害
Elena Obrador1,2, Ali Jihad-Jebbar1, Rosario Salvador-Palmer1
1Department of Physiology, Faculty of Medicine and Odontology, University of Valencia, 46010 Valencia, Spain.
电磁场 (EMF) 和高热量 (HT) 的结合显著降低了癌细胞的活力. 这种组合,加上化疗或向治疗,使得癌症在体外和体内完全消除.
科学领域:
- 在瘤学瘤学.
- 生物物理学的生物物理.
- 纳米医学是一种纳米医学.
背景情况:
- 非电离辐射 (NIR) 在癌症治疗中的应用目前有限.
- 生物相容的磁性纳米粒子被探索为热介质,但需要更高效的纳米材料.
- 开发新的策略来提高癌症治疗效率至关重要.
研究的目的:
- 研究外部应用的电磁场 (EMF) 和高温 (HT) 对瘤细胞活力的联合影响.
- 探索将EMF和HT与化疗或向疗法结合用于癌症治疗的潜力.
- 在体内评估一种结合电磁场和高强度聚焦超声波 (HIFU) 诱导的HT的实验装置.
主要方法:
- 在体外研究中,人类癌症细胞系 (黑色素瘤,胰腺,乳腺) 暴露于EMF和/或HT.
- 在体内实验中,在AsPC1异种移植上使用了一种与EMF和HIFU诱导的HT集成的装置.
- 分析了细胞活力,溶酶体透性,甲素释放和线粒体通路.
主要成果:
- 单独的EMF或HT在体外对癌细胞活性的影响有限.
- 电磁场和HT的组合显著降低了不同癌症细胞系 (16-50%的对照) 的活力.
- 结合疗法 (EMF,HT,化疗/向疗法) 在体外完全消除癌细胞,体内完全回归瘤.
结论:
- 电磁场和HT的结合是提高癌症治疗疗效的有希望的策略.
- 这种综合方法通过溶酶体和线粒体路径诱导癌细胞死亡.
- 结合疗法的进一步开发有可能成为有效的瘤疗法.
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