相关实验视频

Updated: Jul 23, 2025

A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy

A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy

Published on: February 21, 2025

在CAR-T细胞疗法后的克隆性髓质质变形:还是蛋?

Vladimir Vainstein¹, Batia Avni², Sigal Grisariu²

¹Department of Hematology, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91121, Israel.

|July 14, 2023

概括

对多发性骨髓瘤 (MM) 的化学抗原受体T细胞 (CART) 治疗可能会促进现有的骨髓质疏松综合征 (MDS) 克隆,而不是导致新的克隆. 这项研究探讨了在MM患者中CART治疗和MDS发展之间的联系.

科学领域:

血液学血液学血液学
在瘤学瘤学.
免疫治疗是一种免疫疗法.

背景情况:

多发性骨髓瘤 (MM) 经常复发,需要多种治疗线.
诸如化剂和免疫调节剂之类的治疗方法与二次恶性瘤有关,包括骨髓质疏松综合征 (MDS).
抗BCMA CART疗法在复发性/耐药性MM中显示出有效性,但像MDS这样的长期并发症需要进一步调查.

研究的目的:

调查抗BCMA CART治疗与多发性骨髓瘤患者中MDS发展之间的潜在因果关系.
探索CART疗法是否会导致MDS或促进先前存在的MDS克隆.

主要方法:

对五名复发/耐药多发性骨髓瘤患者的回顾性分析,这些患者接受了抗BCMA CART治疗.
在CART治疗前后的骨髓样本中检查与MDS相关的形态和突变变化.

主要成果:

五分之四的患者在CART治疗后发展了MDS;一个人以前有MDS.
在CART治疗前,在后来发展的四名患者中没有观察到MDS的形态变化.
这四名患者在CART治疗前后都存在与MDS相关的分子变化,没有检测到新的突变.

结论:

抗BCMA CART疗法可能会促进多发性骨髓瘤患者中先前存在的MDS克隆的扩张.
根据这项初步研究,CART治疗似乎不会导致新的MDS克隆的发展.
需要进一步的研究才能充分了解CART治疗对MDS发展的长期影响.

关键词:

在CART治疗中,使用CART疗法.多发性骨髓瘤是多发性骨髓瘤的一种.骨髓分裂性综合征是什么?

更多相关视频

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Published on: February 17, 2022

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Published on: December 17, 2019

相关概念视频

T Cell Activation and Clonal Selection

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

Differentiation of Common Myeloid Progenitor Cells

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...