基于PMMA的复合骨水泥的物理,机械和生物特性,含有入银的生物活性和抗菌玻璃颗粒,具有不同的颗粒大小
Marta Miola1, Giovanni Lucchetta2, Enrica Verné1
1Applied Science and Technology Department, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, Italy.
Materials (Basel, Switzerland)
|July 14, 2023
概括
这项研究通过添加生物活性玻璃开发了一种抗菌骨水泥. 较小的玻璃颗粒可以在不损害强度的情况下提高抗菌性能,从而使其在关节和脊柱手术中具有潜在的用途.
科学领域:
- 生物材料科学 生物材料科学
- 整形外科手术 整形外科手术
- 材料工程 材料工程 材料工程
背景情况:
- 骨质水泥对于骨科手术至关重要.
- 感染是关节置换术后的一个重大并发症.
- 开发无抗生素的抗菌骨是可取的.
研究的目的:
- 设计和表征一种抗菌复合骨水泥.
- 评估生物活性玻璃添加对水泥性能的影响.
- 为了研究玻璃颗粒大小对性能的影响.
主要方法:
- 将生物活性抗菌玻璃纳入商业骨质水泥配方.
- 评估固化参数,聚合动力学和符合ISO标准.
- 评估玻璃分散,机械强度 (压缩和曲),生物活性,以及对S. aureus的抗菌功效.
主要成果:
- 聚合动力学延迟了,但符合ISO标准.
- 观察到良好的玻璃分散和表面暴露.
- 生物活性和压力强度不受玻璃颗粒大小的影响.
- 较大的玻璃颗粒略微降低了曲强度和减少了抗菌作用.
结论:
- 量身定制玻璃数量和尺寸可以产生多功能骨.
- 优化的复合骨水泥适用于人工关节固定,临时假肢和脊椎手术.
- 颗粒大小是实现所需抗菌性能的关键因素.
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