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形成水凝的微针在口腔疾病管理中的应用
Yuqing Li1, Duohang Bi2, Zhekai Hu3
1Periodontology and Implant Dentistry, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.
Materials (Basel, Switzerland)
|July 14, 2023
概括
形成水凝的微针 (HFMs) 为口服药物输送提供了一种新的方法,克服了诸如唾液稀释等挑战. 这些微针在牙科中提供了持续的,特定地点的治疗应用.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 口腔卫生技术 口腔卫生技术
背景情况:
- 可控口服药物递送面临诸多挑战,包括细菌污染,唾液稀释和酶失活等.
- 微针为药物管理提供了微侵袭性,特定于位点的解决方案.
- 水凝形成微针 (HFMs) 正在成为牙科诊断和治疗的有希望的技术.
研究的目的:
- 审查形成水凝的微针在牙科中的应用.
- 讨论HFMs在口服药物输送中的基本影响,优势和局限性.
- 探索HFMs在口腔中的未来前景.
主要方法:
- 对牙科应用中形成水凝的微针的现有文献的审查.
- 对包括动物实验和临床试验在内的研究进行分析.
- 讨论聚合物组成 (例如,PVA,PVP) 和交联剂 (例如,酸).
主要成果:
- 在穿透角层和胀后,HFM能够持续通过皮肤或膜传递药物.
- 微针贴片为各种牙科治疗提供无,无痛的药物输送到口腔粘膜.
- 确定的局限性包括药物携带能力的限制和有限数量的牙科临床试验.
结论:
- 形成水凝的微针在特定部位的口服药物输送中具有显著的优势,提高了患者的服药性.
- 需要进一步的研究和临床试验来克服局限性,并充分实现HFMs在牙科中的潜力.
- HFMs对局部麻醉,口腔管理和牙周治疗的未来进步充满希望.
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