在儿童炎症性肠病的过程中胰腺的参与-一个多中心研究
Urszula Daniluk1, Paulina Krawiec2, Elżbieta Pac-Kożuchowska2
1Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, 15-274 Bialystok, Poland.
胰腺干扰发生在超过11%的儿科炎性肠病 (IBD) 患者中,通常呈现为急性胰腺炎或胰腺酶升高. 建议进行常规监测,特别是在阿扎西奥普林治疗期间.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 肝病学和胰腺学 肝病学和胰腺学
- 炎症性肠道疾病研究研究
背景情况:
- 炎症性肠病 (IBD) 和胰腺病理的同时存在在儿科患者中并不常见.
- 了解IBD儿童胰腺感染的频率和病因对于有效的治疗至关重要.
研究的目的:
- 在被诊断为IBD的儿童中,确定胰腺炎和无症状超血症 (HL) 或超血症 (HA) 的发生率和原因.
- 分析胰腺干扰 (PI) 与IBD严重程度和治疗相关的特征.
主要方法:
- 从2014年至2021年间诊断出1538名患有IBD的儿童的数据进行了回顾性分析.
- 在研究队列中评估胰腺参与,包括急性胰腺炎 (AP),HA和HL.
主要成果:
- 在11.4%的儿科IBD患者 (176名儿童) 中发现了胰腺干扰 (PI).
- 急性胰腺炎 (AP) 发生在43.8%的PI患者中,而HA或HL在50.0%的患者中.
- 异常性PI最常见 (57%),其次是药物诱导的PI (37%),尤其是阿扎西奥普林 (AZA) 诱导的PI.
结论:
- 建议对儿科IBD患者进行胰腺酶的常规监测,特别是在开始AZA治疗后.
- 在IBD中,过渡性超胺血症/超脂血症并不总是意味着显著的胰腺病理.
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