母亲吸烟和先天的上肢和下肢差异:系统性审查和元分析
Jevan Cevik1,2, Omar Salehi1,2, James Gaston1,2
1Department of Plastic and Reconstructive Surgery, Peninsula Health, Melbourne, VIC 3199, Australia.
Journal of clinical medicine
|July 14, 2023
概括
怀孕期间母亲吸烟显著增加了先天性肢体缩小缺陷和婴儿某些数字异常的风险. 这凸显了对孕妇戒烟计划的迫切需要.
科学领域:
- 产科和妇科 产科和妇科
- 儿科健康 儿科健康
- 公共卫生 公共卫生
背景情况:
- 怀孕期间母亲吸烟是不良胎儿结果的已知危险因素.
- 以前的研究表明,母亲吸烟与先天性四肢异常之间存在联系,但需要更新证据.
研究的目的:
- 系统地审查和更新关于孕妇在怀孕期间吸烟与先天四肢异常风险之间的联系的证据.
- 使用元分析量化风险.
主要方法:
- 进行了系统的文献搜索,截至2023年2月.
- 包括关于母亲吸烟和先天四肢异常的报告研究.
- 进行了元分析,以计算聚合几率比率 (OR) 和95%置信区间 (CI).
主要成果:
- 分析包括37篇出版物 (11个队列,26个病例控制).
- 发现先天性肢体缩小缺陷的风险显著增加 (总体OR:1.27,95%CI:1.18-1.38).
- 综合的多达克提利/Syndactyly/Adactyly (合并OR: 1.32,95%CI: 1.25-1.40) 观察到显著的关联,但单独的多达克提利或Syndactyly却没有.
结论:
- 怀孕期间母亲吸烟与先天性四肢异常的风险增加有关.
- 研究结果强调了吸烟对胎儿四肢发育的有害影响.
- 孕妇戒烟干预措施对于降低风险至关重要.
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