在患有阻塞性睡眠呼吸暂停的患者中,和度低于80%的时间与90%的时间相比
András Bikov1,2, Stefan Frent3, Oana Deleanu4
1Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Oxford Road, Manchester M13 9WL, UK.
Journal of clinical medicine
|July 14, 2023
概括
更深度的夜间低氧症 (TST80%) 对预测阻塞性睡眠呼吸暂停 (OSA) 患者心血管风险的TST90%提供了有限的额外价值,尽管严重的低氧症与嗜睡相关.
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 通过TST90%量化的夜间低氧症可能比AHI更好地预测阻塞性睡眠呼吸暂停 (OSA) 的心血管结果.
- 严重的低氧化可能导致更严重的病理生理后果.
- 在OSA心血管风险评估中,TST80%到TST90%的附加值仍未得到充分研究.
研究的目的:
- 调查TST80%与TST90%相比,对于OSA患者心血管风险的额外预测值.
- 探索更深层次的低氧症水平与心血管风险因素之间的关系.
主要方法:
- 在797名来自匈牙利和罗马尼亚队伍的参与者中,评估了病史,脂质概况和C反应性蛋白水平.
- 睡眠参数包括AHI,TST90%和TST80%通过多睡眠学或心肺呼吸学多图学进行测量.
- 使用回归分析和ROC曲线,对心血管风险的TST80%和TST90%预测性能进行了比较.
主要成果:
- 无论是TST90%还是TST80%,都显示出与心血管风险因素的显著关联.
- 与TST90%相比,TST80%对心血管风险没有提供更好的预测值.
- 低氧血症的严重程度增加与日间过度嗜睡程度的增加相关.
结论:
- 在TST90%之外,TST80%的临床实用性是最小的,用于评估OSA患者的心血管风险.
- 虽然较深的低氧化症与睡眠增加有关,但其在心血管风险预测中的作用并没有被TST80%增强.
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