评估新型Myval气球可扩展与Evolut:一个倾向匹配的研究
Jonathan Halim1, Maxim Rooijakkers2, Peter den Heijer1
1Department of Cardiology, Amphia Hospital Breda, Molengracht 21, 4818 CK Breda, The Netherlands.
Journal of clinical medicine
|July 14, 2023
概括
Myval气球扩展和Evolut自扩展在严重的大动脉狭窄的治疗中显示出相似的安全性和有效性. 与Evolut SE门相比,Myval BE门所需的永久起器植入量要少得多.
科学领域:
- 心脏病学 心脏病学
- 干预心脏病学 干预心脏病学
- 生物材料科学 生物材料科学
背景情况:
- Myval气球可扩展 (BE) 门展示了有希望的早期临床结果.
- 使用已建立的门进行比较研究是有限的.
- 这项研究将Myval BE与Evolut自扩展 (SE) 进行比较.
研究的目的:
- 为了比较Myval BE门和Evolut SE门的临床性能.
- 评估严重大动脉狭窄症患者的安全性和疗效结果.
- 评估程序并发症和长期结果的差异.
主要方法:
- 一项回顾性单中心研究包括223名患有严重大动脉狭窄症的患者.
- 患者接受了Myval BE门 (n=120) 或Evolut SE门 (n=103).
- 分析了91对匹配对的30天和1年的结果,30天后进行心声回声扫描.
主要成果:
- 在这两组中,程序性并发症是罕见的.
- 在30天和1年内,心脏病死亡或中风没有显著差异.
- 在Myval BE门组中,需要永久心脏起器植入 (PPI) 的数量显著减少 (4%对15%,p=0.01).
- 中度至严重的膜外泄率 (PVL) 是相似的 (1%与4%,p=0.17).
结论:
- Myval BE 门和 Evolut SE 门具有可比的安全性和有效性,长达 1 年.
- 一个显著的差异是,使用Myval BE门的永久起器植入率较低.
- 两个门都显示出出色的血液动力学和中度至严重的门外泄漏率较低.
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