持续增加血清费里水平,尽管转换为永久的血管接入在儿科血液透析患者: 儿科脏学研究联盟研究研究
Ali Mirza Onder1,2, Md Abu Yusuf Ansari3, Fang Deng4
1Division of Pediatric Nephrology, Batson Children's Hospital of Mississippi, University of Mississippi, Jackson, MS 39216, USA.
Journal of clinical medicine
|July 14, 2023
概括
在儿童转换为血液透析 (HD) 的永久血管接入 (PVA) 后,血清费里水平增加. 在儿科患者中观察到的这种增加令人担忧,并需要进一步调查其原因.
科学领域:
- 儿科脏病学 儿科脏病学
- 血管接入 血管接入
- 血液透析是血液透析的方法之一.
背景情况:
- 开始进行血液透析 (HD) 的儿童通常会暂时使用道化管 (TCC).
- 转换为永久血管接入 (PVA) 是管理儿科HD患者的关键步骤.
- 了解PVA后的生理变化对于优化患者护理至关重要.
研究的目的:
- 分析从TCC转换为PVA的儿科患者血清费里丁水平趋势.
- 为了确定与PVA后血清费里水平升高相关的因素.
- 在这个人群中评估血清费里和血红素之间的关系.
主要方法:
- 在20个中心对98名儿科HD患者进行了回顾性图表审查.
- 在PVA形成时和转化后两年测量的血清费里水平.
- 分析包括动脉静脉 (AVF) 和动脉静脉移植 (AVG) 类型.
- 多重线性回归用于识别血清费里丁的预测因子.
主要成果:
- 在PVA生成时血清费里水平显著升高 (562.64 ± 492.34 ng/mL).
- 费里丁水平在第一年显著增加 (753.84 ± 561.54 ng/mL),并在第二年保持高 (759.60 ± 528.11 ng/mL).
- 血清费里丁和血红素之间没有发现显著的线性关联.
- 类固醇耐药性性综合征,高注册中心和基线费里预测了更高的水平.
结论:
- 在儿科HD患者转换为PVA后,血清费里水平显著增加.
- 这种增加与血红素水平无关,是一种令人担忧的趋势.
- 建议进一步研究转林和和费里相关性.
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