胎儿的炎症和免疫反应作为母亲对COVID-19的反应
Nilufar R Gashimova1, Liudmila L Pankratyeva2,3, Victoria O Bitsadze1
1Sechenov University, 2 bldg. 4, Bolshaya Pirogovskaya Str., 119991 Moscow, Russia.
Journal of clinical medicine
|July 14, 2023
概括
怀孕期间的COVID-19感染可以在新生儿中引发胎儿炎症反应综合征,这是免疫系统激活和高水平的炎症性细胞因子所表明的. 孕产妇感染的严重程度不能预测新生儿炎症反应的严重程度.
科学领域:
- 免疫学 免疫学 免疫学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 新生儿科学 新生儿科学
背景情况:
- 怀孕妇女的COVID-19对母亲和胎儿都有风险.
- 怀孕期间的生理变化增加了对严重呼吸道病毒感染的易感性.
- 无症状的母体COVID-19可以导致胎儿炎症反应综合征.
研究的目的:
- 评估胎儿对母体COVID-19的炎症反应.
- 确定促炎性细胞因子和细胞标记物的水平.
- 评估胎儿的心脏功能和胸腺大小.
主要方法:
- 对92名孕妇 (62名COVID-19阳性,30名对照) 的前性研究.
- 在母体和带血液中分析细胞因子,化学因子和细胞标记物.
- 对T调控细胞和T细胞反应的评估.
- 新生儿甲状腺功能测试,胸腺超声波和心声回声.
主要成果:
- 患有COVID-19的母亲的新生儿在树突细胞上增加了CD80/CD86表达.
- 在带血中增加CD4+CCR7+T细胞和减少天真CD4+T细胞.
- 在暴露的新生儿中,高水平的促炎细胞因子和抑制的T细胞调节功能.
- 观察到小结腺体大小的减少,过渡性低甲氧化血和心脏功能变化.
结论:
- 母亲COVID-19可以诱导婴儿的胎儿炎症反应综合征.
- 通过胎儿免疫激活和增加的促炎性细胞因子的特征.
- 新生儿炎症反应的严重程度独立于母亲的疾病严重程度.
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