在sarcopenic肥胖症中,身体成分含量与肝纤维化之间的关联
Tae-Hoon Kim1, Chang-Won Jeong1, ChungSub Lee1
1Medical Convergence Research Center, Wonkwang University, Wonkwang University Hospital, Iksan 54538, Republic of Korea.
Journal of clinical medicine
|July 14, 2023
概括
肥胖症患者表现出内脂肪和皮下脂肪组织的增加,这有助于肝纤维化进展. 这种内脏脂肪积累,以及BMI和AST水平,与SO患者的纤维化严重程度密切相关.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 身体组成分析 身体成分分析
- 慢性肝脏疾病 慢性肝脏疾病
背景情况:
- 肥胖症 (SO) 与代谢和肝脏疾病有关.
- SO和肝纤维化进展之间的关系尚不清楚.
研究的目的:
- 为了比较非肥胖 (NOb) 和SO患者的身体组成.
- 为了研究肝纤维化和SO因子之间的关联.
主要方法:
- 从2014年6月到2020年12月,对60名患者 (28 NOb, 32 SO) 的回顾性研究.
- 腹部MRI评估肌肉区域 (MA),皮下脂肪组织 (SAT) 和内脏脂肪组织 (VAT) 在L3.
- 使用METAVIR评分系统分阶段的肝纤维化.
主要成果:
- SO患者的SAT和VAT显著高于NOb患者 (p < 0.001).
- 在MA/SAT,MA/VAT和MA/...SAT+VAT比率中观察到显著的差异 (p < 0.001).
- 在SO患者中,肝纤维化与BMI,AST和VAT正相关,与肌肉与脂肪的比率 (MA/VAT,MA/(SAT+VAT)) 负相关.
结论:
- SO的特点是与NOb相比,内脏和皮下脂肪增加.
- 在SO的肝纤维化与内脏脂肪,BMI和AST水平显著相关.
- 这些发现突显了体脂肪成分在SO患者肝纤维化发展中的作用.
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