肺移植接受者和COVID-19:两例病例报告
Filippo Antonacci1, Matteo Petroncini1, Elena Salvaterra2
1Thoracic Surgery, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
Journal of clinical medicine
|July 14, 2023
概括
对于肺移植接受者来说,COVID-19仍然是一个严重的风险,即使在流行病紧急情况之后. 病例研究表明,这些脆弱患者的结果严重,并发症恶化.
科学领域:
- 免疫学 免疫学 免疫学
- 移植医学 移植医学
- 传染性疾病 传染性疾病
背景情况:
- COVID-19 (冠状病毒疾病2019) 继续构成重大健康风险,特别是在免疫力低下的人群中.
- 与普通人群相比,肺移植接受者面临的SARS-CoV-2 (严重急性呼吸系统综合征冠状病毒2) 感染的预后更差.
- 在这个特定的患者群体中,COVID-19的长期影响和挑战需要进一步调查.
研究的目的:
- 介绍两个案例研究,说明COVID-19对肺移植接受者的严重影响.
- 要突出不可预测的临床过程和快速恶化的潜力.
- 为了强调预先存在的肺部并发症的恶化.
主要方法:
- 对两名被诊断患有COVID-19的肺移植接受者的回顾性分析.
- 详细审查临床表现,疾病进展和结果.
- 检查先前存在的疾病,如慢性肺异位移植排斥 (CLAD) 和支气管狭窄症.
主要成果:
- 案例1:一个双边肺移植接受者经历了快速恶化和死亡,由于广泛的肺部参与,尽管最初的过程有利.
- 案例2:一个肺移植接受者与先前存在的CLAD和支气管狭窄症显示COVID-19感染后的快速临床下降和恶化的狭窄症.
- 这两起病例都强调了COVID-19在这个人群中的严重性和经常不可预测性.
结论:
- 肺移植接受者是脆弱群体,需要对COVID-19保持高度警.
- COVID-19可以不可预测地恶化现有的肺部疾病,并导致严重的后果.
- 严格的预防措施,包括疫苗接种和感染控制,至关重要. 有针对性的干预措施需要进一步的研究.
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