贝纳利祖马布在患有严重酸性喘的患者中:一个多中心的现实生活体验
Giulia Scioscia1, Pasquale Tondo1, Santi Nolasco2
1Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.
Journal of clinical medicine
|July 14, 2023
概括
从梅波利祖马布转换为本拉利祖马布,改善了在患有严重酸性喘且反应不佳的患者的喘控制. 患有鼻多重症的患者特别受益于这种生物切换.
科学领域:
- 肺部病理学 肺部病理学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 梅波利祖马布和本拉利祖马布在严重的异酸性喘中准抗干流素-5 (IL-5) 途径.
- 这些生物药物减少了恶化和口服皮质类固醇 (OCS) 的需求.
- 由于疾病异质性,正在探索生物药物之间的治疗切换,但从mepolizumab切换到benralizumab需要进一步调查.
研究的目的:
- 评估转换为本拉利祖马布的有效性,在严重埃索诺菲尔性喘患者中,患者对梅波利祖马布的反应不足最佳.
- 为了确定与更好地响应本拉利祖马布转换后的临床因素.
- 评估喘控制,OCS使用和恶化率的变化.
主要方法:
- 在意大利6个中心对25名严重的酸性喘患者进行了回顾性分析,这些患者从美波利祖马布转换为本拉利祖马布.
- 纳入标准:至少12个月后对梅波利祖马布的低于最佳反应 (通过恶化,症状或OCS使用来定义).
- 收集的数据包括喘控制测试 (ACT) 评分,SABA吸入量,OCS剂量和恶化率.
主要成果:
- 转换为本拉利祖马布显著增加了ACT得分 (20.24对16.77),并在6个月和12个月后减少了SABA吸入和OCS/普雷尼松剂量.
- 贝纳利祖马布治疗改善了喘控制,抑制了血液中的乙氨基酸,并减少了恶化.
- 在患有严重酸性喘和鼻多重症的患者中观察到显著的改善.
结论:
- 患有严重埃索诺菲尔性喘,对梅波利祖马布表现出部分反应的患者可能会从转换为本拉利祖马布中受益.
- 治疗转换为本拉利祖马布对于患有并发性鼻多重症的患者尤其有效.
- 这项研究支持本拉利祖马布作为耐火性严重酸性喘的可行治疗选择.
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