在外围插入中央导管的患者中与血栓形成相关的生物标志物:系统性审查和元分析
Patrícia Cristina Cardoso1, Eneida Rejane Rabelo-Silva1,2,3, Patricia Martins Bock4
1Graduate Program in Cardiology and Cardiovascular Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-003, RS, Brazil.
Journal of clinical medicine
|July 14, 2023
概括
高水平的D-二聚体和血小板水平表明,在外围插入中央导管 (PICC) 的患者中,存在深静脉血栓形成 (DVT) 的风险. 其他测试的生物标志物与PICC相关的DVT无关.
科学领域:
- 生物医学研究的研究.
- 临床诊断 临床诊断 临床诊断
- 血管医学是一种血管医学.
背景情况:
- 血生物标志物有助于估计风险和诊断深静脉血栓症 (DVT).
- 外围插入的中央导管 (PICC) 与DVT风险有关.
- 确定与PICC相关的DVT的可靠生物标志物对于患者管理至关重要.
研究的目的:
- 系统地审查和元分析各种生物标志物与PICC相关的DVT之间的关联.
- 在PICC-DVT中识别反映血液系统激活,血管并发症和炎症的生物标志物.
- 为了确定这些生物标志物的诊断或预后价值.
主要方法:
- 在7个电子数据库中进行系统的文献搜索,截至2022年12月.
- 包括比较患有和没有PICC相关DVT报告生物标志物水平的患者的研究.
- 使用纽卡斯尔-太华尺度和发现的元分析进行质量评估.
主要成果:
- 分析包括了28项研究.
- 升高的D-二元水平与PICC相关的DVT显著相关 (p=0.04).
- 血小板数量的增加也与PICC相关的DVT有关 (p=0.02).
结论:
- 在患有PICC的患者中,高的D-二聚体和血小板水平与DVT有关.
- 包括APTT,纤维素原,FDP,葡萄糖,血红蛋白,HbA1c,INR,PT,PF1.2,TAT和WBC在内的生物标志物没有发现与PICC-DVT的发展有关.
- 进一步的研究可能会完善D-二次体和血小板在PICC-DVT风险分层中的作用.
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