初始瘤坏死因子-阿尔法和内皮激活与体外膜氧化过程中的出血并发症有关
Jin Ho Jang1,2, Kyung-Hwa Shin3, Hye Rin Lee2
1Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan 50612, Republic of Korea.
Journal of clinical medicine
|July 14, 2023
概括
瘤亡因子-α (TNF-α) 和其他炎症标志物预测体外膜氧化 (ECMO) 患者的出血风险. 高水平的TNF-α,组织因子和E-selectin在ECMO治疗期间显著预测出血并发症.
科学领域:
- 关键护理医学 关键护理医学
- 心血管研究研究心血管研究
- 血液学 血液学 血液学
背景情况:
- 关于在体外膜氧化 (ECMO) 过程中炎症标记物和内皮激活的研究有限.
- 了解ECMO患者的出血并发症对于改善结果至关重要.
研究的目的:
- 研究成年ECMO患者的炎症标志物和内皮激活与出血并发症之间的关联.
- 为了确定ECMO治疗期间出血风险的预测标志物.
主要方法:
- 未来从132名成年ECMO患者收集血液样本.
- 测量瘤亡因子-α (TNF-α),组织因子 (TF),可溶性血栓模块素 (sTM) 和E-选择素水平.
- 考克斯比例危险回归分析,以评估出血并发症的预测因素,调整临床因素.
主要成果:
- 最初的TNF-α,TF,sTM,E-selectin和活性蛋白C水平与出血并发症 (p < 0.001) 有显著的关联.
- 与单独的临床因素相比,TNF-α,TF和E-selectin在预测出血的准确性更高 (AUC:0.914,0.915,0.869与0.804).
结论:
- 提升的TNF-α水平是经过ECMO的患者出血并发症的重要预测因素.
- 炎症标志物为预测ECMO期间出血风险提供了宝贵的见解,可能指导临床管理.
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