人类血液微生物组的诊断潜力:我们在梦想还是清醒?
Francesca Sciarra1, Edoardo Franceschini1, Federica Campolo1
1Department of Experimental Medicine, Sapienza University of Rome, 00185 Rome, Italy.
International journal of molecular sciences
|July 14, 2023
概括
人类血液微生物群,以前被认为是无菌的,主要在特定的血液细胞中容纳各种细菌. 它的干扰可能是各种疾病的信号,包括心血管和脏疾病.
科学领域:
- 微生物学 微生物学
- 人类健康 人类健康 人类健康
- 疾病生物标志物 疾病生物标志物
背景情况:
- 从历史上看,人类的血液被认为是无菌的.
- 最近的研究揭示了复杂的血液微生物群,其中占主导地位的是Firmicutes,Actinobacteria,Proteobacteria和Bacteroidetes.
- 这些微生物定位在特定的血细胞群体内,特别是外周血液单核细胞和红细胞.
研究的目的:
- 审查关于人类血液微生物组的最新发现.
- 总结最近关于其成分,来源和临床意义的证据.
- 探索血液微生物群失生症作为各种疾病的预后标记物的作用.
主要方法:
- 关于人类血液微生物组的最新研究的文献综述.
- 分析与血液中的微生物组成和定位相关的发现.
- 综合证据,将血液微生物组失调与特定疾病状态联系起来.
主要成果:
- 健康人体血液中存在着多样化的微生物群,主要存在于外周血液单核细胞和红细胞中.
- 皮肤-口腔-肠轴是血液微生物组的假设起源.
- 血液微生物组失调与心血管疾病,肝硬化,严重的肝纤维化,严重的急性胰腺炎,2型糖尿病和慢性病有关.
结论:
- 人类血液微生物组是一个重要的研究领域,具有潜在的诊断和预后影响.
- 需要进一步的研究,以充分理解血液微生物组在健康和疾病中的作用.
- 血液微生物群的失生症可以作为几个慢性和危急疾病的早期指标.
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