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在健康和疾病中的微血管骨肌肉交叉

Gerald J Pepe¹, Eugene D Albrecht^2,3

¹Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA 23501, USA.

International journal of molecular sciences

|July 14, 2023

概括

骨肌肉依赖于肌细胞和血管细胞之间的复杂通信来进行发育,功能和修复. 这篇评论探讨了内皮细胞-卫星细胞交叉交谈对于肌肉恒温和再生至关重要.

科学领域:

肌肉生理学肌肉生理学
血管生物学血管生物学
细胞信号传输细胞信号传输

背景情况:

骨肌肉对于能量生产,葡萄糖平衡和血管健康至关重要.
恒常性需要肌体和血管组件之间的通信.
内皮细胞 (EC) 和肌源性前体在整个发育和再生过程中相互作用.

研究的目的:

审查血管和肌源性血统建立中的细胞信号事件.
检查肌肉发育和肌肉维护中的内皮细胞-卫星细胞 (SC) 交叉对话.
讨论血管肌细胞相互作用,胰岛素/雌激素效应以及骨肌肉病理.

主要方法:

关于胚胎细胞信号的文献综述.
对产后肌肉中EC-SC相互作用的分析.
检查血管 - 肌细胞交叉交谈和荷尔蒙影响.
在肌肉再生和疾病中对EC-SC相互作用的审查.

主要成果:

胚胎信号建立了血管和肌源性血统.
欧盟 - 苏格兰协会交叉通话对于苏格兰协会维护和血管肌生成至关重要.
胰岛素和雌激素显著影响肌肉血管扩张,葡萄糖吸收和生长.
功能障碍的微血管 - 肌细胞相互作用有助于胰岛素抵抗和高血压.
骨肌肉血管系统在杜氏肌肉衰竭中起作用.

结论:

肌肉和血管系统之间的交叉交谈对骨肌肉功能,平衡和再生至关重要.
了解这些相互作用是解决代谢和血管疾病的关键.
雌激素影响胎儿肌肉发育和产后代谢/血管健康.

关键词:

交叉谈话交叉谈话交叉谈话糖尿病糖尿病患者糖尿病患者胎儿的胎儿是一个胎儿.这种高血压,高血压.胰岛素耐药性是一种胰岛素耐药性.微血管系统的形成这是骨肌肉的骨架肌肉.

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