性别在患有刺激性肠综合征的患者中影响肠道微生物群
Paulina Pecyna1, Marcin Gabryel2, Dorota Mankowska-Wierzbicka2
1Chair and Department of Genetics and Pharmaceutical Microbiology, Poznan University of Medical Sciences, 60-806 Poznan, Poland.
International journal of molecular sciences
|July 14, 2023
概括
刺激性肠综合征 (IBS) 患者的肠道微生物群比健康人群多样化. 性别显著影响肠道微生物群的组成,但IBS亚型没有.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
- 人类健康 人类健康 人类健康
背景情况:
- 刺激性肠综合征 (IBS) 是一种普遍存在的功能性胃肠道疾病,影响约11%的人口.
- 人们越来越认识到肠道微生物群是IBS病变的一个关键因素.
- 了解IBS相关的肠道微生物群变化对于开发向疗法至关重要.
研究的目的:
- 为了研究IBS患者和健康对照人群之间的肠道微生物群差异.
- 分析性别和IBS亚型 (罗马IV标准:IBS-C,IBS-D,IBS-M,IBS-U) 对肠道微生物群组成的影响.
- 为了确定与IBS相关的特定微生物种群.
主要方法:
- 来自121名IBS患者和70名健康对照者的便样本的16S rRNA扩增序列测序.
- 肠道微生物群多样性和组成的比较分析.
- 基于IBS亚型和患者性别的数据分层.
主要成果:
- 与不受影响的个体相比,IBS患者的肠道微生物群显著多样化.
- 在包括 *Clostridiales*, *Mogibacteriaceae*, *Synergistaceae*, *Coriobacteriaceae*, *Blautia* spp. 和 *Shuttleworthia* spp. 在内的种类中,注意到了特定的差异.
- 肠道微生物群在女性中表现出比男性更大的差异化,无论IBS状态如何. 在IBS亚型和微生物群组成之间没有发现相关性.
结论:
- 在IBS患者中,肠道微生物群的多样性发生了改变.
- 性别是IBS研究肠道微生物群特征的一个重要因素.
- IBS亚型的分类似乎没有影响观察到的肠道微生物群差异.
相关概念视频
Irritable Bowel Syndrome I: Introduction
322
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
322
Anatomy of the Intestines
72.6K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
72.6K
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
195
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
195
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
357
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
357
Irritable Bowel Syndrome III: Medical and Nursing Management
244
Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
244
Chronic Bowel Disorders: Introduction
489
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
489


