绿色合成和功能性两块共聚物的评估作为一个状黄素输送系统
Radostina Kalinova1, Georgy Grancharov1, Jordan Doumanov2
1Institute of Polymers, Bulgarian Academy of Sciences, Akad. G. Bonchev St., bl. 103-A, 1113 Sofia, Bulgaria.
International journal of molecular sciences
|July 14, 2023
概括
研究人员使用可生物降解和生物相容块开发了聚合物微粒的绿色合成. 这些稳定,无毒的菌体显示出希望作为药物输送纳米载体,用于诸如癌症治疗等应用.
科学领域:
- 聚合物化学 聚合物化学
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
背景情况:
- 聚合物微粒由于可适应的宏分子设计,提供了多功能药物输送平台.
- 环保的合成方法越来越重要,以聚合物为基础的纳米药物输送系统.
研究的目的:
- 开发一种无溶剂的绿色合成路径,用于两双块共聚物.
- 为潜在的纳米载体应用创建自组装聚合物米塞尔.
- 为了评估加载和初步的体外疗效的曲素加载的小粒.
主要方法:
- 大量有机催化,无金属环开聚合一种功能性碳酸盐单体.
- 使用甲聚乙烯甘醇 (PEG) 作为一个宏观发起者.
- 具有特征的自组装小粒 (平均直径44纳米),并装有黄素.
主要成果:
- 通过使用绿色,无溶剂的方法成功合成了一种两性双块共聚物.
- 在水性介质中形成了平均直径为44nm的稳定聚合物微粒.
- 在试验室中,含有黄素的菌体初步显示出无毒性.
结论:
- 开发的绿色合成过程产生了适合菌形成的功能性两类块共聚物.
- 由此产生的聚合物微粒是稳定的,无毒的,有效的黄素载体.
- 这些发现突显了这些细胞作为生物医学应用中的纳米载体的潜力.
关键词:
两性共聚物是两性共聚物.抗氧化剂活性 抗氧化剂活性库尔库明是一种黄素.细胞毒性 细胞毒性药物输送是药物输送的过程.功能性聚合物 米塞尔.纳米载体的纳米载体没有溶剂的无溶剂聚合.稳定的稳定性 稳定的稳定性更多相关视频
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