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使用和Ag/AgCl电极对终端皮层潜力的比较研究

Bulat Mingazov¹, Daria Vinokurova¹, Andrei Zakharov^1,2

¹Laboratory of Neurobiology, Kazan Federal University, Kazan 420008, Russia.

International journal of molecular sciences

|July 14, 2023

概括

通过比较和Ag/AgCl电极,可以发现不同的末端脑损伤标志物. 电极检测到Ag/AgCl电极中缺少的晚期,大负超慢电位 (NUP) 阶段,表明对与脑死亡相关的因素的敏感性.

科学领域:

神经科学是一个神经科学.
电子生理学电子生理学
脑损伤研究脑损伤研究

背景情况:

大脑缺血导致皮质电压变化,包括扩散脱极化 (SD) 和负超慢电位 (NUP),作为大脑损伤的标记.
电极材料和放置显著影响SD和NUP的记录特征.

研究的目的:

使用 (Ir) 和银/银化物 (Ag/AgCl) 电极在麻醉安乐死期间比较末端皮层事件.
研究电极类型之间记录传播脱极化 (SD) 和负超慢电位 (NUP) 的差异.

主要方法:

在大鼠体感皮层中利用了皮层内线性电极阵列和基于Ag/AgCl的电极.
在异花或异花安乐死期间记录的皮质电活动,监测超极化,SD和NUPs.

主要成果:

两种电极类型都检测到超极化,SD和早期NUP阶段的麻醉后引起的呼吸停止.
Ag/AgCl电极记录了钟形的NUP,在30分钟内减少.
电极记录了双相NUP,包括早期阶段和晚期,渐进的脱极化转移,在两个小时内达到-100mV,在更深的皮层中幅度更大.

结论:

皮层内Ag/AgCl和Ir电极可靠地检测早期脑损伤标志物,如超极化,SD和早期NUP.
仅用Ir电极观察到的晚期,大幅度的NUP阶段表明对与大脑死亡相关的未确定因素的敏感性.

关键词:

皮层扩散脱极化死亡死亡死亡死亡死亡死亡一般麻醉全身麻醉全球脑缺血病全球脑缺血病负的超慢潜力是一个负的超慢潜力.新皮质新皮质的新皮质呼吸停止是指呼吸停止的情况.

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